Add to ORKGCharacterizing genetic variability in the human pathogenic Plasmodium species, the group of parasites that cause Malaria, may have broad global health implications. Specifically, discerning the combinations of mutations that lead to viable parasites and the population level frequencies of these clonal sequences will allow for targeted vaccine development and individualized treatment choices. This presents an analytical challenge, however, since haplotypic phase (i.e. the alignment of bases on a single DNA strand) is generally unobservable in multiply infected individuals. This manuscript describes an expectation maximization (EM) approach to maximum likelihood estimation of haplotype frequencies in this missing data setting. The approa...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
Background Haplotypes are important in anti-malarial drug resistance because genes encoding drug ...
As many malaria-endemic countries move towards elimination of Plasmodium falciparum, the most virule...
Characterizing genetic variability in the human pathogenic Plasmodium species, the group of parasite...
BACKGROUND: Reliable measures of anti-malarial resistance are crucial for malaria control. Resistanc...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
Malaria is an infectious disease that is caused by a group of parasites of the genus Plasmodium. Cha...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
Malaria kills hundreds of thousands of people each year, yet is entirely curable given prompt treatm...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
We present a Bayesian approach for estimating the relative frequencies of multi-single nucleotide po...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
Background Haplotypes are important in anti-malarial drug resistance because genes encoding drug ...
As many malaria-endemic countries move towards elimination of Plasmodium falciparum, the most virule...
Characterizing genetic variability in the human pathogenic Plasmodium species, the group of parasite...
BACKGROUND: Reliable measures of anti-malarial resistance are crucial for malaria control. Resistanc...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
Malaria is an infectious disease that is caused by a group of parasites of the genus Plasmodium. Cha...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
Malaria kills hundreds of thousands of people each year, yet is entirely curable given prompt treatm...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
We present a Bayesian approach for estimating the relative frequencies of multi-single nucleotide po...
The introduction of genomic methods facilitated standardized molecular disease surveillance. For ins...
Background Haplotypes are important in anti-malarial drug resistance because genes encoding drug ...
As many malaria-endemic countries move towards elimination of Plasmodium falciparum, the most virule...