A number of events in the U.S. and abroad have refocused the scientific community on historical issues of whether, and how, integrity of our technical literature can be assured. Solutions to this problem are neither simple nor certain. Professional societies have addressed scientific misconduct, and effective responses by the research community will require cooperation of scientific publications. While the incidence of scientific fraud is difficult to estimate with precision and certainly varies with discipline, identified and publicized recent cases beg attention from editorial boards. Several egregious cases are described. The peer review system serves the function of examination and critique by scientists in relevant disciplines to asses...