Brucella abortus is a facultative intracellular gram-negative bacterium that causes chronic protracted infections of humans and livestock. It is also a potential biowarfare agent and thus development of vaccines for humans is an important goal. In mice infected with Brucella abortus, protective roles for CD4 and CD8 T cells have been demonstrated. A critical role for T cells is likely to be production of IFNγ as IFNγ-deficient mice succumb to brucellosis. Here we show both T cell subsets contribute to control of infection by virulent strain B. abortus 2308 by producing IFNγ and CD4 T cells but not CD8 T cells facilitate clearance of infection. Strikingly, antibody-independent B cell functions contribute to the development of the high platea...
Stealthy intracellular bacterial pathogens are known to establish persistent and sometimes life-long...
Brucellosis is a common zoonotic disease that remains endemic in many parts of the world. Dissecting...
Immune responses appropriate for control of an intracellular pathogen are generated in mice infected...
Brucella spp. are facultative intracellular bacterial pathogens responsible for brucellosis, a world...
Brucella spp. are facultative intracellular bacterial pathogens responsible for brucellosis, a world...
γδ T cells have been postulated to act as a first line of defense against infectious agents, particu...
Background. Brucella species are facultative intracellular bacteria that cause lifelong infections i...
BALB/c mice infected with Brucella abortus strain 2308 have 10-fold higher levels of bacteria during...
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Brucellosis is a d...
The mucosal immune system represents the first line of defense against Brucella infection in nature....
Prior to these studies, the literature indicated an essential role for CD8+ T cell-mediated cytotoxi...
Cellular immune responses are a critical part of the host's defense against intracellular bacterial ...
Brucella are facultative intracellular bacteria that chronically infect humans and animals causing b...
Brucella are facultative intracellular bacteria that chronically infect humans and animals causing b...
Immune responses appropriate for control of an intracellular pathogen are generated in mice infected...
Stealthy intracellular bacterial pathogens are known to establish persistent and sometimes life-long...
Brucellosis is a common zoonotic disease that remains endemic in many parts of the world. Dissecting...
Immune responses appropriate for control of an intracellular pathogen are generated in mice infected...
Brucella spp. are facultative intracellular bacterial pathogens responsible for brucellosis, a world...
Brucella spp. are facultative intracellular bacterial pathogens responsible for brucellosis, a world...
γδ T cells have been postulated to act as a first line of defense against infectious agents, particu...
Background. Brucella species are facultative intracellular bacteria that cause lifelong infections i...
BALB/c mice infected with Brucella abortus strain 2308 have 10-fold higher levels of bacteria during...
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Brucellosis is a d...
The mucosal immune system represents the first line of defense against Brucella infection in nature....
Prior to these studies, the literature indicated an essential role for CD8+ T cell-mediated cytotoxi...
Cellular immune responses are a critical part of the host's defense against intracellular bacterial ...
Brucella are facultative intracellular bacteria that chronically infect humans and animals causing b...
Brucella are facultative intracellular bacteria that chronically infect humans and animals causing b...
Immune responses appropriate for control of an intracellular pathogen are generated in mice infected...
Stealthy intracellular bacterial pathogens are known to establish persistent and sometimes life-long...
Brucellosis is a common zoonotic disease that remains endemic in many parts of the world. Dissecting...
Immune responses appropriate for control of an intracellular pathogen are generated in mice infected...