Cell adhesion is fundamental to establishing and maintaining the discrete tissues in multicellular organisms. Adhesion must be sufficiently strong to preserve tissue architecture, whilst having the capacity to readily dissociate to permit fundamental processes, such as wound repair, to occur. However, very little is known about the signalling mechanisms involved in temporary down-regulation of cell adhesion to facilitate such processes. Cadherins are the principal mediators of cell-cell adhesion in a wide variety of tissues and species and form multi-protein complexes with cytosolic and cytoskeletal proteins to express their full adhesive capacity. In the present study we report that the p85 subunit of phosphoinositide 3-kinase (PI 3-kinase...
Proper regulation of the formation and stabilization of epithelial cell–cell adhesion is crucial in ...
Adhesion proteins maintain cell-cell interactions, which are critical for tissue formation and the h...
AbstractThe multi-functional protein β-catenin plays essential roles in cell–cell adhesion and nucle...
Cell-cell adhesion is central to morphogenesis and maintenance of epithelial cell state. We previous...
Abstract Ca 2+ -dependent cell-cell adhesion is regulated by the cadherin family of cell adhesion pr...
Epithelia are the interface between the outside environment and us, and form very important tissue s...
<div><p>Tight regulation of cadherin-mediated intercellular adhesions is critical to both tissue mor...
Adhesion receptors of the classical cadherin family have a major role in establishing tissue organiz...
Cadherin cell adhesion molecules are major determinants of tissue patterning which function in coope...
Classical cadherin adhesion molecules can function as adhesion-activated cell-signaling receptors. O...
Human intestinal cell differentiation is mediated by signaling pathways that remain largely undefine...
E-cadherins are surface adhesion molecules localized at the level of adherens junctions, which play ...
Cadherin-based cell–cell contacts are prominent sites for phosphotyrosine signaling, being enriched ...
Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are li...
Cells in our body utilize a variety of adaptor proteins for transmitting context specific signals th...
Proper regulation of the formation and stabilization of epithelial cell–cell adhesion is crucial in ...
Adhesion proteins maintain cell-cell interactions, which are critical for tissue formation and the h...
AbstractThe multi-functional protein β-catenin plays essential roles in cell–cell adhesion and nucle...
Cell-cell adhesion is central to morphogenesis and maintenance of epithelial cell state. We previous...
Abstract Ca 2+ -dependent cell-cell adhesion is regulated by the cadherin family of cell adhesion pr...
Epithelia are the interface between the outside environment and us, and form very important tissue s...
<div><p>Tight regulation of cadherin-mediated intercellular adhesions is critical to both tissue mor...
Adhesion receptors of the classical cadherin family have a major role in establishing tissue organiz...
Cadherin cell adhesion molecules are major determinants of tissue patterning which function in coope...
Classical cadherin adhesion molecules can function as adhesion-activated cell-signaling receptors. O...
Human intestinal cell differentiation is mediated by signaling pathways that remain largely undefine...
E-cadherins are surface adhesion molecules localized at the level of adherens junctions, which play ...
Cadherin-based cell–cell contacts are prominent sites for phosphotyrosine signaling, being enriched ...
Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are li...
Cells in our body utilize a variety of adaptor proteins for transmitting context specific signals th...
Proper regulation of the formation and stabilization of epithelial cell–cell adhesion is crucial in ...
Adhesion proteins maintain cell-cell interactions, which are critical for tissue formation and the h...
AbstractThe multi-functional protein β-catenin plays essential roles in cell–cell adhesion and nucle...