During pregnancy, CRH and CRH-related peptides appear to regulate the fetoplacental circulation via activation of the nitric oxide (NO)/ cGMP pathway. Pregnancies with abnormal placental function such as preeclampsia ( PE) are characterized by increased maternal plasma CRH concentrations and reduced placental CRH-receptor 1 alpha (CRH-R1 alpha) expression. In this study, we investigated the actions of CRH/ CRH-related peptides on the NO/cGMP system in normal and PE placentas ( n = 8 for each group). Fluorescent in situ hybridization, RT-PCR, and immunofluorescence experiments in human term placenta detected mRNAs expression for both R1 and R2 types of CRH-R, as well as urocortin (UCN) II and UCN III and showed CRH-R protein expression mai...
Corticotrophin-releasing hormone (CRH) is the hypothalamic peptide that controls the function of the...
Preeclampsia has several pathophysiological pathways, but the placenta has a central role. The patho...
It is now accepted that, in humans, placental corticotrophin-releasing hormone (CRH) is involved in ...
This study has used an in vitro perfusion method to investigate the mechanism by which CRH causes va...
Corticotropin releasing hormone (CRH) is produced in intrauterine sites including the placenta, deci...
Placentally derived CRH seems to play a major role in the mechanisms controlling human pregnancy and...
Premature birth is the major source of perinatal death and disability. Furthermore, the intrauterine...
Placentally derived CRH plays a major role in the mechanisms controlling human pregnancy and parturi...
Despite intense studies preeclampsia remains enigmatic and a major cause of maternal and fetal morbi...
The complex mechanisms controlling human parturition involves mother, fetus, and placenta, and stres...
The placenta is central to foetal growth and development in mammalian pregnancy. Compromised placent...
Context: The pathogenesis of preterm delivery (PTD) is not clear, although inflammation/infection pl...
Corticotropin-releasing hormone (CRH) is a 41 amino acid polypeptide that exerts a wide spectrum of ...
Objective: Urocortin 2 (Ucn2) and urocortin 3 (Ucn3) are new members of the corticotrophin-releasing...
Corticotrophin-releasing hormone (CRH) causes vasodilatation in the human fetal-placental circulatio...
Corticotrophin-releasing hormone (CRH) is the hypothalamic peptide that controls the function of the...
Preeclampsia has several pathophysiological pathways, but the placenta has a central role. The patho...
It is now accepted that, in humans, placental corticotrophin-releasing hormone (CRH) is involved in ...
This study has used an in vitro perfusion method to investigate the mechanism by which CRH causes va...
Corticotropin releasing hormone (CRH) is produced in intrauterine sites including the placenta, deci...
Placentally derived CRH seems to play a major role in the mechanisms controlling human pregnancy and...
Premature birth is the major source of perinatal death and disability. Furthermore, the intrauterine...
Placentally derived CRH plays a major role in the mechanisms controlling human pregnancy and parturi...
Despite intense studies preeclampsia remains enigmatic and a major cause of maternal and fetal morbi...
The complex mechanisms controlling human parturition involves mother, fetus, and placenta, and stres...
The placenta is central to foetal growth and development in mammalian pregnancy. Compromised placent...
Context: The pathogenesis of preterm delivery (PTD) is not clear, although inflammation/infection pl...
Corticotropin-releasing hormone (CRH) is a 41 amino acid polypeptide that exerts a wide spectrum of ...
Objective: Urocortin 2 (Ucn2) and urocortin 3 (Ucn3) are new members of the corticotrophin-releasing...
Corticotrophin-releasing hormone (CRH) causes vasodilatation in the human fetal-placental circulatio...
Corticotrophin-releasing hormone (CRH) is the hypothalamic peptide that controls the function of the...
Preeclampsia has several pathophysiological pathways, but the placenta has a central role. The patho...
It is now accepted that, in humans, placental corticotrophin-releasing hormone (CRH) is involved in ...