Positive correlation between serum omentin and thrombospondin-1 in gestational diabetes despite lack of correlation with insulin resistance indices

Gestational Diabetes (GDM) is characterized by insulin resistance and a pro-inflammatory state, both factors possible related to adipokine expression. Subjects and Methods: The study included 20 women with GDM, diagnosed according to the WHO criteria, and 23 matched for age and BMI women with normal glucose tolerance. Omentin and TSP-1 were measured by ELISA assays. Insulin resistance was assessed by NOMA and Insulin Resistance Index (IRI). Results: There were no significant differences in omen tin and TSP-1 levels between subjects with GDM and controls (48.0 +/- 12.0ng/ml versus 50.2 +/- 7.9ng/ml and 2150 +/- 1661ng/ml versus 1569 +/- 1160ng/ml, p=0.64 and p=0.29, for omentin and TSP-1 in GDM and control subjects, respectively). There was no significant correlation between either omen tin or TSP-1 with HOMA or IRI, however there was a significant positive correlation between thrombospondin-1 and omentin (r=0.49, p=0.010). There was also a positive correlation between serum omentin and glucose levels at 60 and 90 minutes of OGTT, however in the control group only (p