Systemic and pulmonary hemodynamics assessed with a lumped-parameter heart-arterial interaction model

Arterial pressure and flow result from the interaction between the ( actively) ejecting ventricle and the ( passive) arterial circulation. The main objective was to construct a model, accounting for this interaction, that is simple enough so that (i) model parameters can be derived from data measured in experimental and/or clinical conditions, and (ii) the model can be applied to support the analysis and interpretation of these data. It is demonstrated how an established conceptual model of ventricular function ( the time-varying elastance) can be coupled to a four-element windkessel model of the arterial system to yield an elegant model of heart-arterial interaction. The coupling leads to a set of three ordinary differential equations. The model allows the study of the effect of changes in cardiac and/or arterial properties on arterial pressure and flow. As an illustration, cardiac and arterial model parameters are derived from measured experimental data in the systemic circulation of a pig and in the pulmonary circulation of a dog. It is evaluated how well measured cardiac and arterial function actually adhere to their assumed theoretical models (time-varying elastance and four-element windkessel model). It is further assessed how well the simple model of heart-arterial interaction describes systemic and pulmonary hemodynamics by comparing simulated and measured experimental data. The limitations and pitfalls of the model, as well as possible applications in the clinical field, are discussed