Voxel-based distribution of metabolic impairment in corticobasal degeneration

Garraux, Gaëtan
Salmon, Eric
Peigneux, Philippe
Kreisler, Alexandre
Degueldre, Christian
Lemaire, Christian
Destee, Alain
Franck, Georges

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Publication date

September 2000

DOI

10.1002/1531-8257(200009)15:5

Publisher

John Wiley & Sons

ISSN

0885-3185

Abstract

peer reviewedThis report emphasizes the precise topographic distribution of cerebral metabolic impairment in corticobasal degeneration (CBD) and the pathophysiological differences between CBD and progressive supranuclear palsy (PSP). Statistical parametric mapping (SPM96) analysis of 18FDG positron emission tomography (PET) data was performed in 22 patients with CBD compared with 46 healthy subjects (HS) and 21 patients with PSP who were studied at rest. A statistical threshold of p <0.001 was fixed, further corrected for multiple or independent comparisons (p <0.05). In comparison with HS, the metabolic impairment in CBD was asymmetrically distributed in the putamen, thalamus, precentral (Brodmann's area, BA 4), lateral premotor (BA 6/44) ...