Effect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER.
- Mogensen, Carl Erik
- Viberti, Giancarlo
- Halimi, Serge
- Ritz, Eberhard
- Ruilope, Luis
- Jermendy, Gyorgy
- Widimsky, Jiri
- Sareli, Pinchas
- Taton, Jan
- Rull, Juan
- Erdogan, Gurbuz
- De Leeuw, Pieter W
- Ribeiro, Arthur
- Sanchez, Ramiro
- Mechmeche, Rachid
- Nolan, John
- Sirotiakova, Jana
- Hamani, Ahmed
- Scheen, André
- Hess, Bernhard
- Luger, Anton
- Thomas, Stephen M
DOIAbstract
Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril monotherapy on albumin excretion rate (AER) in patients with type 2 diabetes, albuminuria, and hypertension in a 12-month, randomized, double-blind, parallel-group international multicenter study. Four hundred eighty-one patients with type 2 diabetes and hypertension (systolic BP > or =140 mm Hg, 20 and <500 microg/min were randomly assigned to a combination of 2 mg perindopril/0.625 mg indapamide or to 10 mg daily enalapril. After week 12, doses were adjusted on the basis of BP to a maximum of 8 mg perindopril/2.5 mg indapamide or 40 mg e...
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