The use of recombinant human erythropoietin (rhEPO) to intensify the erythropoietic response in autologous donors may reduce homologous blood requirement. We studied the effect of subcutaneous rhEPO (500 U kg-1 body weight twice weekly during a 3 week period) on variables of erythropoiesis and iron metabolism in 62 autologous blood donors, of whom 32 received rhEPO (epo group) and 30 did not (control group). Patients donated only 2 units of blood and received oral iron in order to restrict phlebotomy-induced decrease of iron stores. Pre-phlebotomy haemoglobin concentration (14.0 +/- 0.8 g dl-1) was completely regenerated in the epo group at surgery (13.7 +/- 1.3 g dl-1); haemoglobin concentration in the control group fell from 13.5 +/- 1.4 ...
Recombinant human erythropoietin is used in clinical practice mainly for treatment of anemia of rena...
Recombinant human erythropoietin is used in clinical practice mainly for treatment of anemia of rena...
Iron status in patients receiving erythropoietin for dialysis-associated anemia. Adequate body iron ...
Limited red blood cell (RBC) regeneration often prevents collection of sufficient blood from autolog...
BACKGROUND: Recombinant human erythropoietin (rHuEPO) therapy improves the success of autologous blo...
Objective: To optimise collection of sufficient autologous blood for elective surgery.Methods: Prosp...
The high iron demand associated with enhanced erythropoiesis during high-altitude hypoxia leads to s...
The high iron demand associated with enhanced erythropoiesis during high-altitude hypoxia leads to s...
The variations in plasma erythropoietin (EPO) concentration during preoperative deposit of autologou...
The variations in plasma erythropoietin (EPO) concentration during preoperative deposit of autologou...
BACKGROUND. Anaemia is a frequent finding in patients with cancer and may be due to different causes...
The plasma concentrations of erythropoietin (Ep), soluble transferrin receptors (sTfRs), iron, total...
Erythropoietin hyporesponsiveness: From iron deficiency to iron overload. Iron deficiency is the mos...
A randomized controlled study of iron supplementation in patients treated with erythropoietin. In vi...
Recombinant human erythropoietin (rHuEPO) stimulates erythropoietic bone marrow cells and increases ...
Recombinant human erythropoietin is used in clinical practice mainly for treatment of anemia of rena...
Recombinant human erythropoietin is used in clinical practice mainly for treatment of anemia of rena...
Iron status in patients receiving erythropoietin for dialysis-associated anemia. Adequate body iron ...
Limited red blood cell (RBC) regeneration often prevents collection of sufficient blood from autolog...
BACKGROUND: Recombinant human erythropoietin (rHuEPO) therapy improves the success of autologous blo...
Objective: To optimise collection of sufficient autologous blood for elective surgery.Methods: Prosp...
The high iron demand associated with enhanced erythropoiesis during high-altitude hypoxia leads to s...
The high iron demand associated with enhanced erythropoiesis during high-altitude hypoxia leads to s...
The variations in plasma erythropoietin (EPO) concentration during preoperative deposit of autologou...
The variations in plasma erythropoietin (EPO) concentration during preoperative deposit of autologou...
BACKGROUND. Anaemia is a frequent finding in patients with cancer and may be due to different causes...
The plasma concentrations of erythropoietin (Ep), soluble transferrin receptors (sTfRs), iron, total...
Erythropoietin hyporesponsiveness: From iron deficiency to iron overload. Iron deficiency is the mos...
A randomized controlled study of iron supplementation in patients treated with erythropoietin. In vi...
Recombinant human erythropoietin (rHuEPO) stimulates erythropoietic bone marrow cells and increases ...
Recombinant human erythropoietin is used in clinical practice mainly for treatment of anemia of rena...
Recombinant human erythropoietin is used in clinical practice mainly for treatment of anemia of rena...
Iron status in patients receiving erythropoietin for dialysis-associated anemia. Adequate body iron ...