The effect of antioxidant supplement on exercise in simulated hypoxia treatment.

[[abstract]]Purpose: To investigate the effect of antioxidant supplement on oxidative stress in 4800 m test. Methods: Twelve healthy college students were subjected to two trials: placebo trial and antioxidant trial (600 mg α-lipoic acid, 1000 mg vitamin C, and 400 IU vitamin E). Plasma and RBC levels of thiobarbituric acid reactive substancesm (TBARS), Plasma and RBC glutathione peroxidase activity (GPx), Plasma and RBC catalase activity (CAT), Plasma and RBC superoxide dismutase activity (SOD), lactate, glucose, carbonyl protein, uric acid were measured before treated with supplement (rest), before 4800 m test (pre), after 4800 m test (pt0’), post 30 minute (pt30’), post 60 minute (pt60’), post 1 day (pt1d), post 3 days (pt3d). Results: The 4800 m test significantly increased in the concentration of RBC TBARS for both trials. Antioxidant trial reduced TBARS in pt30’. Control trial had significantly increased in the concentration of plasma TBARS at pt3d. Placebo trial level of uric acid was increased significantly following the 4800 m test. Conclusion: Antioxidant supplement can reduce oxidative stress from 4800 m test within 30 min. Also, it no significantly increased in oxidative stress for 3 days.