[[alternative]]The Effects of Consecutive Training on T-lymphocyte in Healthy Hepatitis B Carriers

[[abstract]]The purpose of this study was to investigate the effects of five-day consecutive training on T-lymphocyte in healthy hepatitis B carriers. Sixteen athletes (age=20.7±1.6 yrs, ht=177.1±5.1 cm, wt=71±7.9 kg, VO2max=52.7±5.4 ml/kg/min) from different sport teams were recruited as the subjects. Eight of the subjects who were healthy hepatitis B carriers served as the experimental group (B group), and the other eight normal healthy subjects was the Control group. All subjects were asked to run on treadmill at 75%VO2max, 30 minutes per day for five consecutive days. The blood samples were collected on day one at pre-exercise, day five at pre-exercise, post-exercise, 1.5 hr, 3 hr and 24 hr post-exercise. The T-lymphocyte number, its subpopulations (CD3+,CD4+CD8-,CD4-CD8+), and T-lymphocyte proliferation were measured and analyzed by two-way ANCOVA mixed design. The results indicated that there was no significant difference between B group and Control group on T-lymphocyte number, its subpopulations, and T-lymphocyte proliferation at any time. But the numbers of leukocyte, lymphocyte, T cell, CD4+CD8- cells and CD4-CD8+cells in all subjects were significantly increased immediately after exercise on day five. Then, those parameters were dramatically decreased at 1.5 hr post-exercise, which were significantly lower than pre-exercise on day one. In addition, the CD4/CD8 ratio was significantly decreased immediately after exercise on day five. T-lymphocyte proliferation was significantly suppressed at 1.5 hr post-exercise on day five. In summary, the immunological response to five-day consecutive training in healthy hepatitis B carriers was not different from that of normal healthy people. However, all subjects were undergone immunological suppression around 1-3 hr of recovery period after the consecutive training.