peer reviewedOligonucleotides (ONs) and more particularly siRNAs are promising drugs but their pharmacokinetics and biodistribution are widely unknown. Positron Emission Tomography (PET) using fluorine-18 is a suitable technique to quantify these biological processes. Click chemistry (Huisgen cycloaddition) is the current method for labeling siRNA. In order to study the influence of a linker bearing by [18F]labeled ONs, on the in vivo pharmacokinetic and metabolism, we have developed two modified ONs by two news linkers. Here we report the synthesis of two alkyne-bearing linkers, the incorporation onto a ONs and the conjugation by click chemistry with a [18F]prosthetic group.OligoPE
Due to expanding applications of positron emission tomography (PET) there is a demand for developing...
In oncology and neurology the F-18-radiolabeled glucose analogue 2-deoxy-2-[F-18]fluoro-D-glucose ([...
A range of resin bound sulfonate ester linkers were developed for use in the resin-linker-vector (RL...
For more than 3 decades, oligonucleotides have been used for therapies, imaging and diagnostics. The...
Click chemistry : radiolabelling of oligonucleotides with fluorine-18 for PET imaging Oligonucleo...
Oligonucleotides (ONs), especially small interfering RNA (siRNA), are promising therapeutic agents, ...
Positron Emission Tomography is a highly sensitive imaging technique currently available in nuclear ...
Introduction: Positron emission tomography (PET) is a high-resolution, sensitive, molecular and func...
Molecular imaging has been defined as the in vivo characterization and measurement of biological pro...
The use of peptides or proteins labeled with fluorine-18, as agents for Positron Emission Tomography...
The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated ...
La Tomographie par émission de positons (TEP) constitue l’une des techniques d’imagerie médicale les...
Positron emission tomography (PET) is the most sensitive imaging technology in nuclear medicine to m...
Novel probe development for positron emission tomography (PET) is leading to expanding the scope of ...
'Click' chemistry has been widely applied in nucleic acid studies, the most common reactions being t...
Due to expanding applications of positron emission tomography (PET) there is a demand for developing...
In oncology and neurology the F-18-radiolabeled glucose analogue 2-deoxy-2-[F-18]fluoro-D-glucose ([...
A range of resin bound sulfonate ester linkers were developed for use in the resin-linker-vector (RL...
For more than 3 decades, oligonucleotides have been used for therapies, imaging and diagnostics. The...
Click chemistry : radiolabelling of oligonucleotides with fluorine-18 for PET imaging Oligonucleo...
Oligonucleotides (ONs), especially small interfering RNA (siRNA), are promising therapeutic agents, ...
Positron Emission Tomography is a highly sensitive imaging technique currently available in nuclear ...
Introduction: Positron emission tomography (PET) is a high-resolution, sensitive, molecular and func...
Molecular imaging has been defined as the in vivo characterization and measurement of biological pro...
The use of peptides or proteins labeled with fluorine-18, as agents for Positron Emission Tomography...
The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated ...
La Tomographie par émission de positons (TEP) constitue l’une des techniques d’imagerie médicale les...
Positron emission tomography (PET) is the most sensitive imaging technology in nuclear medicine to m...
Novel probe development for positron emission tomography (PET) is leading to expanding the scope of ...
'Click' chemistry has been widely applied in nucleic acid studies, the most common reactions being t...
Due to expanding applications of positron emission tomography (PET) there is a demand for developing...
In oncology and neurology the F-18-radiolabeled glucose analogue 2-deoxy-2-[F-18]fluoro-D-glucose ([...
A range of resin bound sulfonate ester linkers were developed for use in the resin-linker-vector (RL...