The polyamines are of great importance in several biological processes, such as cell proliferation, and differentiation. The ingestion of spermine by suckling rats induces the precocious maturation of their small intestine. This phenomenon is preceded by a cell elimination at the villus tip. We hypothesize that these two phenomena could be mediated by the immune system and thus inhibited by an immunosuppressive agent such as cyclosporine A. Cyclosporine A inhibits, at least partially, the spermine-induced increase of the maltase- and sucrase-specific activities in the small intestine but failed to inhibit lactase-specific activity decrease and cell loss. Spermine does not act by the same mechanism in differentiation and in cell loss. Moreov...
AbstractExposure of several leukaemia cell types to the polyamine spermine triggered caspase activat...
Exposure of HL-60 cells to millimolar levels of spermine resulted in the inhibition of cell growth. ...
Two experimental systems representative of the mitochondrial and death receptor apoptotic pathways a...
Polyamines are of great importance in several physiological processes, such as cell proliferation an...
We have previously shown that spermine, shortly after its ingestion, can induce the alteration of th...
To evaluate the role of dietary polyamines in maturation of the rat small intestine, spermine was gi...
Spermine ingestion induces the precocious maturation of the small intestine in suckling rats. Previo...
Spermine is a low molecular weight polyamine involved in the postnatal maturation of the gut. When i...
peer reviewedIn the present investigation, the authors aimed to evaluate the role of cytokines in in...
Spermine is a low molecular weight polyamine involved in the postnatal maturation of the gut. When i...
Spermine, a low molecular weight polyamine, administered orally to suckling rats induces the maturat...
In the present study, we investigated the effects of spermine on postnatal liver maturation in suckl...
Background The cross-talk between the host and its microbiota plays a key role in the promotion of h...
Department of Pediatrics, Academic Hospital Maastricht, The Netherlands. Enhanced intestinal nitric ...
Department of Biochemistry and General Physiology, University of Liege, Belgium.The effect of oral a...
AbstractExposure of several leukaemia cell types to the polyamine spermine triggered caspase activat...
Exposure of HL-60 cells to millimolar levels of spermine resulted in the inhibition of cell growth. ...
Two experimental systems representative of the mitochondrial and death receptor apoptotic pathways a...
Polyamines are of great importance in several physiological processes, such as cell proliferation an...
We have previously shown that spermine, shortly after its ingestion, can induce the alteration of th...
To evaluate the role of dietary polyamines in maturation of the rat small intestine, spermine was gi...
Spermine ingestion induces the precocious maturation of the small intestine in suckling rats. Previo...
Spermine is a low molecular weight polyamine involved in the postnatal maturation of the gut. When i...
peer reviewedIn the present investigation, the authors aimed to evaluate the role of cytokines in in...
Spermine is a low molecular weight polyamine involved in the postnatal maturation of the gut. When i...
Spermine, a low molecular weight polyamine, administered orally to suckling rats induces the maturat...
In the present study, we investigated the effects of spermine on postnatal liver maturation in suckl...
Background The cross-talk between the host and its microbiota plays a key role in the promotion of h...
Department of Pediatrics, Academic Hospital Maastricht, The Netherlands. Enhanced intestinal nitric ...
Department of Biochemistry and General Physiology, University of Liege, Belgium.The effect of oral a...
AbstractExposure of several leukaemia cell types to the polyamine spermine triggered caspase activat...
Exposure of HL-60 cells to millimolar levels of spermine resulted in the inhibition of cell growth. ...
Two experimental systems representative of the mitochondrial and death receptor apoptotic pathways a...