Estradiol and Progesterone Regulate the Proliferation of Human Breast Epithelial Cells
- Foidart, Jean-Michel
- Colin, Carine
- Denoo, Xavier
- Desreux, Joëlle
- Beliard, Aude
- Fournier, Sbine
- de Lignieres, Bruno
DOIAbstract
OBJECTIVE: To study the effects of estradiol and progesterone on the proliferation of normal human breast epithelial cells in vivo. DESIGN: Double-blind randomized study. SETTING: Departments of gynecology and of cell biology at a university hospital. PATIENT(S): Forty postmenopausal women with untreated menopause and documented plasma FSH levels of >30 mIU/mL and estradiol levels of <20 pg/mL. INTERVENTION(S): Daily topical application to both breasts of a gel containing a placebo, estradiol, progesterone, or a combination of estradiol and progesterone during the 14 days preceding esthetic breast surgery or excision of a benign lesion. MAIN OUTCOME MEASURE(S): Plasma and breast tissue concentrations of estradiol and progesterone. Epithelia...
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