peer reviewedHistone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are therefore promising anti-cancer drugs. The CDK inhibitor p21 is activated in HDAC inhibitor treated tumor cells and its growth-inhibitory function contributes to the anti-tumorigenic effect of HDAC inhibitors. We show here that induction of p21 by trichostatin A involves MAP kinase signaling. Activation of the MAP kinase signaling pathway by growth factors or stress signals results in histone H3 serine 10 phosphorylation at the p21 promoter and is crucial for acetylation of the neighboring lysine 14 and recruitment of activated RNA polymerase II in response to trichostatin A treatment. In non-induced cells, the protein phosphatase PP2A ...
Differential positioning of the histone variant H2A.Z in a p53 dependent manner was shown to regulat...
Histone deacetylase inhibitors (HDIs) are a group of chemo-preventive and chemo-therapeutic agents t...
Although histone deacetylase (HDAC) inhibitors are appreciated as a promising class of anticancer dr...
Histone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are therefo...
AbstractHistone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell c...
Histone deacetylase inhibitors (HDIs) are a group of chemo-preventive and chemo-therapeutic agents t...
AbstractHistone deacetylase inhibitors (HDIs) are thought to act primarily at the level of transcrip...
PubMed ID: 18419600Many studies aim at improving therapeutic efficacy by combining strategies with o...
p21(CDKN1A) (WAF1/CIP1/SDI1), the cyclin-dependent kinase (CDK) inhibitor belonging to the Cip/Kip f...
Histone deacetylases (HDACs) are chromatin-modifying enzymes that are involved in the regulation of ...
Cell cycle progression is regulated by interactions between cyclins and cycl in-dependent kinases (C...
p21(CDKN1A) (WAF1/CIP1/SDI1), the cyclin-dependent kinase (CDK) inhibitor belonging to the Cip/Kip f...
© 2011 Dr. Andrea NewboldThe opposing activities of histone acetyltransferases (HATs) and histone de...
WOS: 000255060600018PubMed ID: 18419600Many studies aim at improving therapeutic efficacy by combini...
AbstractThe cyclin kinase inhibitor p21, originally described as a universal inhibitor of cyclin-dep...
Differential positioning of the histone variant H2A.Z in a p53 dependent manner was shown to regulat...
Histone deacetylase inhibitors (HDIs) are a group of chemo-preventive and chemo-therapeutic agents t...
Although histone deacetylase (HDAC) inhibitors are appreciated as a promising class of anticancer dr...
Histone deacetylase inhibitors induce cell cycle arrest and apoptosis in tumor cells and are therefo...
AbstractHistone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell c...
Histone deacetylase inhibitors (HDIs) are a group of chemo-preventive and chemo-therapeutic agents t...
AbstractHistone deacetylase inhibitors (HDIs) are thought to act primarily at the level of transcrip...
PubMed ID: 18419600Many studies aim at improving therapeutic efficacy by combining strategies with o...
p21(CDKN1A) (WAF1/CIP1/SDI1), the cyclin-dependent kinase (CDK) inhibitor belonging to the Cip/Kip f...
Histone deacetylases (HDACs) are chromatin-modifying enzymes that are involved in the regulation of ...
Cell cycle progression is regulated by interactions between cyclins and cycl in-dependent kinases (C...
p21(CDKN1A) (WAF1/CIP1/SDI1), the cyclin-dependent kinase (CDK) inhibitor belonging to the Cip/Kip f...
© 2011 Dr. Andrea NewboldThe opposing activities of histone acetyltransferases (HATs) and histone de...
WOS: 000255060600018PubMed ID: 18419600Many studies aim at improving therapeutic efficacy by combini...
AbstractThe cyclin kinase inhibitor p21, originally described as a universal inhibitor of cyclin-dep...
Differential positioning of the histone variant H2A.Z in a p53 dependent manner was shown to regulat...
Histone deacetylase inhibitors (HDIs) are a group of chemo-preventive and chemo-therapeutic agents t...
Although histone deacetylase (HDAC) inhibitors are appreciated as a promising class of anticancer dr...