Effect of salt depletion on sodium ion transport from human erythrocytes

This study was realized to test De Wardener's hypothesis on the presence of a plasmatic and natriuretic factor in essential hypertension. By an indirect approach consisting of modification of plasma volume and sodium pool in chronic renal failure and primary hypertension with, at the same time , measurements of ionic flux variations in human erythrocytes, we provide some arguments to confirm the presence of such a factor in hydrosaline overloaded uraemic patients and in "salt-sensitive" essential hypertensive subjects