Objective: Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans and glycemic control and renal function in type 1 diabetes. Research Design and Methods: Using serum samples from 818 adults who were considered to have extreme annual loss in estimated glomerular filtration rate (eGFR; i.e., slope) based on retrospective clinical records, from among 6,127 adults in the Scottish Diabetes Research Network Type 1 Bioresource Study, we measured total and IgG-specific N-glycan profiles. This yielded a relative abundance of 39 total (GP) and 24 IgG (IGP) N-glycans. Linear reg...
Increased protein glycation, oxidation and nitration is linked to the development of diabetic nephro...
Background: Diabetic nephropathy (DN) is a late complication in both type 1 diabetes mellitus (T1DM)...
Background: Albuminuria has been classically considered a marker of kidney damage progression in dia...
Objective: Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulat...
Glycans constitute the most abundant and diverse form of the post-translational modifications, and a...
OBJECTIVE: We investigated in a cross-sectional study the levels of serum and urinary damage markers...
Introduction Inflammatory processes are thought to be involved in kidney function decline in indivi...
BackgroundThe aim of this study was to investigate which glycemic parameters better reflect urinary ...
Objective: To determine the role of markers of plasma protein damage by glycation, oxidation and nit...
International audienceBackground: Hyperglycaemia impairs tubulo-glomerular feedback. We tested wheth...
Increased protein glycation, oxidation and nitration is linked to the development of diabetic nephro...
Background: Diabetic nephropathy (DN) is a late complication in both type 1 diabetes mellitus (T1DM)...
Background: Albuminuria has been classically considered a marker of kidney damage progression in dia...
Objective: Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulat...
Glycans constitute the most abundant and diverse form of the post-translational modifications, and a...
OBJECTIVE: We investigated in a cross-sectional study the levels of serum and urinary damage markers...
Introduction Inflammatory processes are thought to be involved in kidney function decline in indivi...
BackgroundThe aim of this study was to investigate which glycemic parameters better reflect urinary ...
Objective: To determine the role of markers of plasma protein damage by glycation, oxidation and nit...
International audienceBackground: Hyperglycaemia impairs tubulo-glomerular feedback. We tested wheth...
Increased protein glycation, oxidation and nitration is linked to the development of diabetic nephro...
Background: Diabetic nephropathy (DN) is a late complication in both type 1 diabetes mellitus (T1DM)...
Background: Albuminuria has been classically considered a marker of kidney damage progression in dia...