Immune Cross-Opsonization Within emm Clusters Following Group A Streptococcus Skin Infection: Broadening the Scope of Type-Specific Immunity.
- Frost, Hannah R C H.
- Laho, Delphine
- Sanderson-Smith, Martina L
- Licciardi, Paul
- Donath, Susan
- Curtis, Nigel
- Kado, Joseph
- Dale, James B
- Steer, Andrew C
- Smeesters, Pierre
Publication date
October 2017
DOI Publisher
Oxford University Press (OUP) ISSN
1058-4838 Citation count (estimate)
2Abstract
Group A Streptococcus (GAS) skin infections are particularly prevalent in developing nations. The GAS M protein, by which strains are differentiated into >220 different emm types, is immunogenic and elicits protective antibodies. A major obstacle for vaccine development has been the traditional understanding that immunity following infection is restricted to a single emm type. However, recent evidence has led to the hypothesis of immune cross-reactivity between emm types.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
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