Ezrin, radixin, and moesin possess a very similar structure with a C-terminal actin-binding domain and a N-terminal FERM interacting domain. They are known to be involved in cytoskeleton organization in several cell types but their function in vascular smooth muscle cells (VSMC) is still unknown. The aim of this study was to investigate the role of ERM proteins in cell migration induced by PDGF, a growth factor involved in pathophysiological processes like angiogenesis or atherosclerosis. We used primary cultured VSMC obtained from rat aorta, which express the three ERM proteins. Simultaneous depletion of the three ERM proteins with specific siRNAs abolished the effects of PDGF on cell architecture and migration and markedly increased cell ...
ObjectiveUrokinase plasminogen activator (uPA) a key serine protease during remodeling, is capable o...
T cell trafficking between the blood and lymphoid organs is a complex, multistep process that requir...
The vascular wall is an active, elastic and integrated organ made up of cellular and extracellular m...
Ezrin, radixin, and moesin possess a very similar structure with a C-terminal actin-binding domain a...
The contractile tone of smooth muscle cells (VSMC) in the vascular wall controls the blood flow by ...
Ezrin, Radixin, Moesin binding phosphoprotein 50 (EBP50) is a scaffold protein that possesses two PD...
Ezrin, radixin, and moesin (ERM) proteins are known to be substrates of Rho kinase (ROCK), a key pla...
Migration and proliferation of smooth muscle cells (SMC) are important events in the development of ...
An efficient immune system is dependent on many circulating populations of specialized cells. T cell...
OBJECTIVE: Pathophysiological effects of the epidermal growth factor receptor (EGFR or ErbB1) includ...
The focal adhesion (FAK) non-receptor protein-tyrosine kinase (PTK) links both extracellular matrix/...
186 pagesThe plasma membrane and the underlying cortical actin cytoskeleton work together to dynamic...
Turnover of focal adhesions (FAs) is known to be critical for cell migration and adhesion of prolife...
<div><p>Altered phosphorylation status of the C-terminal Thr residues of Ezrin/Radixin/Moesin (ERM) ...
International audienceInteractions between the Eph receptor tyrosine kinase and ephrin ligands trans...
ObjectiveUrokinase plasminogen activator (uPA) a key serine protease during remodeling, is capable o...
T cell trafficking between the blood and lymphoid organs is a complex, multistep process that requir...
The vascular wall is an active, elastic and integrated organ made up of cellular and extracellular m...
Ezrin, radixin, and moesin possess a very similar structure with a C-terminal actin-binding domain a...
The contractile tone of smooth muscle cells (VSMC) in the vascular wall controls the blood flow by ...
Ezrin, Radixin, Moesin binding phosphoprotein 50 (EBP50) is a scaffold protein that possesses two PD...
Ezrin, radixin, and moesin (ERM) proteins are known to be substrates of Rho kinase (ROCK), a key pla...
Migration and proliferation of smooth muscle cells (SMC) are important events in the development of ...
An efficient immune system is dependent on many circulating populations of specialized cells. T cell...
OBJECTIVE: Pathophysiological effects of the epidermal growth factor receptor (EGFR or ErbB1) includ...
The focal adhesion (FAK) non-receptor protein-tyrosine kinase (PTK) links both extracellular matrix/...
186 pagesThe plasma membrane and the underlying cortical actin cytoskeleton work together to dynamic...
Turnover of focal adhesions (FAs) is known to be critical for cell migration and adhesion of prolife...
<div><p>Altered phosphorylation status of the C-terminal Thr residues of Ezrin/Radixin/Moesin (ERM) ...
International audienceInteractions between the Eph receptor tyrosine kinase and ephrin ligands trans...
ObjectiveUrokinase plasminogen activator (uPA) a key serine protease during remodeling, is capable o...
T cell trafficking between the blood and lymphoid organs is a complex, multistep process that requir...
The vascular wall is an active, elastic and integrated organ made up of cellular and extracellular m...