Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Bitto, Alessandro
Ito, Takashi K.
Pineda, Victor V.
LeTexier, Nicolas J.
Huang, Heather Z.
Sutlief, Elissa
Tung, Herman
Vizzini, Nicholas
Chen, Belle
Smith, Kaleb
Meza, Daniel
Yajima, Masanao
Beyer, Richard P.
Kerr, Kathleen F.
Davis, Daniel J.
Gillespie, Catherine H.
Snyder, Jessica M.
Treuting, Piper M.
Kaeberlein, Matt

August 2016

The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in ...

An aging Interventions Testing Program: study design and interim report

Miller, Richard A.
Harrison, David E.
Astle, Clinton M.
Floyd, Robert A.
Flurkey, Kevin
Hensley, Kenneth L.
Javors, Martin A.
Leeuwenburgh, Christiaan
Nelson, James F.
Ongini, Ennio
Nadon, Nancy L.
Warner, Huber R.
Strong, Randy

August 2007

The National Institute on Aging's Interventions Testing Program (ITP) has developed a plan to evalua...

17‐α estradiol ameliorates age‐associated sarcopenia and improves late‐life physical function in male mice but not in females or castrated males

Garratt, Michael
Leander, Danielle
Pifer, Kaitlyn
Bower, Brian
Herrera, Jonathan J.
Day, Sharlene M.
Fiehn, Oliver
Brooks, Susan V.
Miller, Richard A.

April 2019

Pharmacological treatments can extend mouse lifespan, but lifespan effects often differ between sexe...

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an -glucosidase inhibitor or a Nrf2-inducer

Strong, R
Miller, RA
Antebi, A
Astle, CM
Bogue, M
Denzel, MS
Fernandez, E
Flurkey, K
Hamilton, KL
Lamming, DW
Javors, MA
de Magalhaes, JP
Martinez, PA
McCord, JM
Miller, BF
Muller, M
Nelson, JF
Ndukum, J
Rainger, GE
Richardson, A
Sabatini, DM
Salmon, AB
Simpkins, JW
Steegenga, WT
Nadon, NL
Harrison, DE

October 2016

The National Institute on Aging Interventions Testing Program (ITP ) evaluates agents hypothesized t...

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

Strong, Randy
Miller, Richard A.
Antebi, Adam
Astle, Clinton M.
Bogue, Molly
Denzel, Martin S.
Fernandez, Elizabeth
Flurkey, Kevin
Hamilton, Karyn L.
Lamming, Dudley W.
Javors, Martin A.
de Magalhães, João Pedro
Martinez, Paul Anthony
McCord, Joe M.
Miller, Benjamin F.
Müller, Michael
Nelson, James F.
Ndukum, Juliet
Rainger, G. Ed.
Richardson, Arlan
Salmon, Adam B.
Simpkins, James W.
Steegenga, Wilma T.
Nadon, Nancy L.
Harrison, David E.
Sabatini, David

May 2016

The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to...

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Strong, Randy
Miller, Richard A
Antebi, Adam
Astle, Clinton M
Bogue, Molly A
Denzel, Martin S
Fernandez, Elizabeth
Flurkey, Kevin
Hamilton, Karyn L
Lamming, Dudley W
Javors, Martin A
de Magalhães, João Pedro
Martinez, Paul Anthony
McCord, Joe M
Miller, Benjamin F
Müller, Michael
Nelson, James F
Ndukum, Juliet
Rainger, G Ed
Richardson, Arlan
Sabatini, David M
Salmon, Adam B
Simpkins, James W
Steegenga, Wilma T
Nadon, Nancy L
Harrison, David E

October 2016

The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to...

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an alpha-glucosidase inhibitor or a Nrf2-inducer

Strong, R.
Miller, R.
Antebi, A.
Astle, C.
Bogue, M.
Denzel, M.
Fernandez, E.
Flurkey, K.
Hamilton, K.
Lamming, D.
Javors, M.
de Magalhaes, J.
Martinez, P.
McCord, J.
Miller, B.
Muller, M.
Nelson, J.
Ndukum, J.
Rainger, G.
Richardson, A.
Sabatini, D.
Salmon, A.
Simpkins, J.
Steegenga, W.
Nadon, N.
Harrison, D.

June 2016

The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to...

Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, David E.
Strong, Randy
Allison, David B.
Ames, Bruce N.
Astle, Clinton M.
Atamna, Hani
Fernandez, Elizabeth
Flurkey, Kevin
Javors, Martin A.
Nadon, Nancy L.
Nelson, James F.
Pletcher, Scott
Simpkins, James W.
Smith, Daniel
Wilkinson, J. Erby
Miller, Richard A.

April 2014

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106661/1/acel12170.pd

17- a- estradiol late in life extends lifespan in aging UM- HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Harrison, David E.
Strong, Randy
Reifsnyder, Peter
Kumar, Navasuja
Fernandez, Elizabeth
Flurkey, Kevin
Javors, Martin A.
Lopez‐cruzan, Marisa
Macchiarini, Francesca
Nelson, James F.
Bitto, Alessandro
Sindler, Amy L.
Cortopassi, Gino
Kavanagh, Kylie
Leng, Lin
Bucala, Richard
Rosenthal, Nadia
Salmon, Adam
Stearns, Timothy M.
Bogue, Molly
Miller, Richard A.

May 2021

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the - non- feminizing- ...

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Harrison, David E
Strong, Randy
Reifsnyder, Peter
Kumar, Navasuja
Fernandez, Elizabeth
Flurkey, Kevin
Javors, Martin A
Lopez‐Cruzan, Marisa
Macchiarini, Francesca
Nelson, James F
Markewych, Adrian
Bitto, Alessandro
Sindler, Amy L
Cortopassi, Gino
Kavanagh, Kylie
Leng, Lin
Bucala, Richard
Rosenthal, Nadia
Salmon, Adam
Stearns, Timothy M
Bogue, Molly
Miller, Richard A

May 2021

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the "non-feminizing" estro...

Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Miller, Richard A.
Harrison, David E.
Astle, Clinton M.
Fernandez, Elizabeth
Flurkey, Kevin
Han, Melissa
Javors, Martin A.
Li, Xinna
Nadon, Nancy L.
Nelson, James F.
Pletcher, Scott
Salmon, Adam B.
Sharp, Zelton Dave
Van Roekel, Sabrina
Winkleman, Lynn
Strong, Randy

June 2014

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107367/1/acel12194.pd

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Strong, Randy
Miller, Richard A.
Astle, Clinton M.
Floyd, Robert A.
Flurkey, Kevin
Hensley, Kenneth L.
Javors, Martin A.
Leeuwenburgh, Christiaan
Nelson, James F.
Ongini, Ennio
Nadon, Nancy L.
Warner, Huber R.
Harrison, David E.

October 2008

The National Institute on Aging's Interventions Testing Program was established to evaluate agents t...

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, D E
Strong, R
Allison, D B
Ames, B N

April 2014

Four agents — acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene ...

Male lifespan extension with 17â Î± estradiol is linked to a sexâ specific metabolomic response modulated by gonadal hormones in mice

Garratt, Michael
Lagerborg, Kim A.
Tsai, Yi‐miau
Galecki, Andrzej
Jain, Mohit
Miller, Richard A.

August 2018

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145263/1/acel12786.pdfhttps://deepblue...

Acarbose improves health and lifespan in aging HET3 mice.

Harrison, David E
Strong, Randy
Alavez, Silvestre
Astle, Clinton M
DiGiovanni, John
Fernandez, Elizabeth
Flurkey, Kevin
Garratt, Michael
Gelfond, Jonathan A L
Javors, Martin A
Levi, Moshe
Lithgow, Gordon J
Macchiarini, Francesca
Nelson, James F
Sukoff Rizzo, Stacey J
Slaga, Thomas J
Stearns, Timothy M
Wilkinson, John Erby
Miller, Richard A

April 2019

To follow-up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spi...

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Bitto, Alessandro
Ito, Takashi K.
Pineda, Victor V.
LeTexier, Nicolas J.
Huang, Heather Z.
Sutlief, Elissa
Tung, Herman
Vizzini, Nicholas
Chen, Belle
Smith, Kaleb
Meza, Daniel
Yajima, Masanao
Beyer, Richard P.
Kerr, Kathleen F.
Davis, Daniel J.
Gillespie, Catherine H.
Snyder, Jessica M.
Treuting, Piper M.
Kaeberlein, Matt

August 2016

The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in ...

An aging Interventions Testing Program: study design and interim report

Miller, Richard A.
Harrison, David E.
Astle, Clinton M.
Floyd, Robert A.
Flurkey, Kevin
Hensley, Kenneth L.
Javors, Martin A.
Leeuwenburgh, Christiaan
Nelson, James F.
Ongini, Ennio
Nadon, Nancy L.
Warner, Huber R.
Strong, Randy

August 2007

The National Institute on Aging's Interventions Testing Program (ITP) has developed a plan to evalua...

17‐α estradiol ameliorates age‐associated sarcopenia and improves late‐life physical function in male mice but not in females or castrated males

Garratt, Michael
Leander, Danielle
Pifer, Kaitlyn
Bower, Brian
Herrera, Jonathan J.
Day, Sharlene M.
Fiehn, Oliver
Brooks, Susan V.
Miller, Richard A.

April 2019

Pharmacological treatments can extend mouse lifespan, but lifespan effects often differ between sexe...

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an -glucosidase inhibitor or a Nrf2-inducer

Strong, R
Miller, RA
Antebi, A
Astle, CM
Bogue, M
Denzel, MS
Fernandez, E
Flurkey, K
Hamilton, KL
Lamming, DW
Javors, MA
de Magalhaes, JP
Martinez, PA
McCord, JM
Miller, BF
Muller, M
Nelson, JF
Ndukum, J
Rainger, GE
Richardson, A
Sabatini, DM
Salmon, AB
Simpkins, JW
Steegenga, WT
Nadon, NL
Harrison, DE

October 2016

The National Institute on Aging Interventions Testing Program (ITP ) evaluates agents hypothesized t...

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

Strong, Randy
Miller, Richard A.
Antebi, Adam
Astle, Clinton M.
Bogue, Molly
Denzel, Martin S.
Fernandez, Elizabeth
Flurkey, Kevin
Hamilton, Karyn L.
Lamming, Dudley W.
Javors, Martin A.
de Magalhães, João Pedro
Martinez, Paul Anthony
McCord, Joe M.
Miller, Benjamin F.
Müller, Michael
Nelson, James F.
Ndukum, Juliet
Rainger, G. Ed.
Richardson, Arlan
Salmon, Adam B.
Simpkins, James W.
Steegenga, Wilma T.
Nadon, Nancy L.
Harrison, David E.
Sabatini, David

May 2016

The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to...

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Strong, Randy
Miller, Richard A
Antebi, Adam
Astle, Clinton M
Bogue, Molly A
Denzel, Martin S
Fernandez, Elizabeth
Flurkey, Kevin
Hamilton, Karyn L
Lamming, Dudley W
Javors, Martin A
de Magalhães, João Pedro
Martinez, Paul Anthony
McCord, Joe M
Miller, Benjamin F
Müller, Michael
Nelson, James F
Ndukum, Juliet
Rainger, G Ed
Richardson, Arlan
Sabatini, David M
Salmon, Adam B
Simpkins, James W
Steegenga, Wilma T
Nadon, Nancy L
Harrison, David E

October 2016

The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to...

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an alpha-glucosidase inhibitor or a Nrf2-inducer

Strong, R.
Miller, R.
Antebi, A.
Astle, C.
Bogue, M.
Denzel, M.
Fernandez, E.
Flurkey, K.
Hamilton, K.
Lamming, D.
Javors, M.
de Magalhaes, J.
Martinez, P.
McCord, J.
Miller, B.
Muller, M.
Nelson, J.
Ndukum, J.
Rainger, G.
Richardson, A.
Sabatini, D.
Salmon, A.
Simpkins, J.
Steegenga, W.
Nadon, N.
Harrison, D.

June 2016

The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to...

Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, David E.
Strong, Randy
Allison, David B.
Ames, Bruce N.
Astle, Clinton M.
Atamna, Hani
Fernandez, Elizabeth
Flurkey, Kevin
Javors, Martin A.
Nadon, Nancy L.
Nelson, James F.
Pletcher, Scott
Simpkins, James W.
Smith, Daniel
Wilkinson, J. Erby
Miller, Richard A.

April 2014

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106661/1/acel12170.pd

17- a- estradiol late in life extends lifespan in aging UM- HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Harrison, David E.
Strong, Randy
Reifsnyder, Peter
Kumar, Navasuja
Fernandez, Elizabeth
Flurkey, Kevin
Javors, Martin A.
Lopez‐cruzan, Marisa
Macchiarini, Francesca
Nelson, James F.
Bitto, Alessandro
Sindler, Amy L.
Cortopassi, Gino
Kavanagh, Kylie
Leng, Lin
Bucala, Richard
Rosenthal, Nadia
Salmon, Adam
Stearns, Timothy M.
Bogue, Molly
Miller, Richard A.

May 2021

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the - non- feminizing- ...

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Harrison, David E
Strong, Randy
Reifsnyder, Peter
Kumar, Navasuja
Fernandez, Elizabeth
Flurkey, Kevin
Javors, Martin A
Lopez‐Cruzan, Marisa
Macchiarini, Francesca
Nelson, James F
Markewych, Adrian
Bitto, Alessandro
Sindler, Amy L
Cortopassi, Gino
Kavanagh, Kylie
Leng, Lin
Bucala, Richard
Rosenthal, Nadia
Salmon, Adam
Stearns, Timothy M
Bogue, Molly
Miller, Richard A

May 2021

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the "non-feminizing" estro...

Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Miller, Richard A.
Harrison, David E.
Astle, Clinton M.
Fernandez, Elizabeth
Flurkey, Kevin
Han, Melissa
Javors, Martin A.
Li, Xinna
Nadon, Nancy L.
Nelson, James F.
Pletcher, Scott
Salmon, Adam B.
Sharp, Zelton Dave
Van Roekel, Sabrina
Winkleman, Lynn
Strong, Randy

June 2014

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107367/1/acel12194.pd

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Strong, Randy
Miller, Richard A.
Astle, Clinton M.
Floyd, Robert A.
Flurkey, Kevin
Hensley, Kenneth L.
Javors, Martin A.
Leeuwenburgh, Christiaan
Nelson, James F.
Ongini, Ennio
Nadon, Nancy L.
Warner, Huber R.
Harrison, David E.

October 2008

The National Institute on Aging's Interventions Testing Program was established to evaluate agents t...

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, D E
Strong, R
Allison, D B
Ames, B N

April 2014

Four agents — acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene ...

Male lifespan extension with 17â Î± estradiol is linked to a sexâ specific metabolomic response modulated by gonadal hormones in mice

Garratt, Michael
Lagerborg, Kim A.
Tsai, Yi‐miau
Galecki, Andrzej
Jain, Mohit
Miller, Richard A.

August 2018

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145263/1/acel12786.pdfhttps://deepblue...

Acarbose improves health and lifespan in aging HET3 mice.

Harrison, David E
Strong, Randy
Alavez, Silvestre
Astle, Clinton M
DiGiovanni, John
Fernandez, Elizabeth
Flurkey, Kevin
Garratt, Michael
Gelfond, Jonathan A L
Javors, Martin A
Levi, Moshe
Lithgow, Gordon J
Macchiarini, Francesca
Nelson, James F
Sukoff Rizzo, Stacey J
Slaga, Thomas J
Stearns, Timothy M
Wilkinson, John Erby
Miller, Richard A

April 2019

To follow-up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spi...

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Bitto, Alessandro
Ito, Takashi K.
Pineda, Victor V.
LeTexier, Nicolas J.
Huang, Heather Z.
Sutlief, Elissa
Tung, Herman
Vizzini, Nicholas
Chen, Belle
Smith, Kaleb
Meza, Daniel
Yajima, Masanao
Beyer, Richard P.
Kerr, Kathleen F.
Davis, Daniel J.
Gillespie, Catherine H.
Snyder, Jessica M.
Treuting, Piper M.
Kaeberlein, Matt

August 2016

The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in ...

An aging Interventions Testing Program: study design and interim report

Miller, Richard A.
Harrison, David E.
Astle, Clinton M.
Floyd, Robert A.
Flurkey, Kevin
Hensley, Kenneth L.
Javors, Martin A.
Leeuwenburgh, Christiaan
Nelson, James F.
Ongini, Ennio
Nadon, Nancy L.
Warner, Huber R.
Strong, Randy

August 2007

The National Institute on Aging's Interventions Testing Program (ITP) has developed a plan to evalua...

17‐α estradiol ameliorates age‐associated sarcopenia and improves late‐life physical function in male mice but not in females or castrated males

Garratt, Michael
Leander, Danielle
Pifer, Kaitlyn
Bower, Brian
Herrera, Jonathan J.
Day, Sharlene M.
Fiehn, Oliver
Brooks, Susan V.
Miller, Richard A.

April 2019

Pharmacological treatments can extend mouse lifespan, but lifespan effects often differ between sexe...

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

Abstract

Extracted data

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

Abstract

Extracted data

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