Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- Nalls, M. A.
- Pankratz, N.
- Lill, C. M.
- Do, C. B.
- Hernandez, D. G.
- Saad, M.
- DeStefano, A. L.
- Kara, E.
- Bras, J.
- Sharma, M.
- Schulte, C.
- Keller, M. F.
- Arepalli, S.
- Letson, C.
- Edsall, C.
- Stefansson, H.
- Liu, X.
- Pliner, H.
- Lee, J. H.
- Cheng, R.
- Ikram, M. A.
- Ioannidis, J. P. A.
- Hadjigeorgiou, G. M.
- Bis, J. C.
- Martinez, M.
- Perlmutter, J. S.
- Goate, A.
- Marder, K.
- Fiske, B.
- Sutherland, M.
- Xiromerisiou, G.
- Myers, R. H.
- Clark, L. N.
- Stefansson, K.
- Hardy, J. A.
- Heutink, P.
- Chen, H.
- Wood, N. W.
- Houlden, H.
- Payami, H.
- Brice, A.
- Scott, W. K.
- Gasser, T.
- Bertram, L.
- Eriksson, N.
- Foroud, T.
- Singleton, A. B.
- Ipdg
- Parkins, G. Parkinson's Study Grp PSG
- AndMe
- GenePd
- Ngrc
- Hihg
- Ashkenazi Jewish Dataset, Investiga
- Charge
- Nabec
- Ukbec
- Greek Parkinson's Dis, Consortium
- Alzheimer Genetic Analysis, Gr
DOIAbstract
We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect of each individual locus was s...
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