Time of sampling is crucial for measurement of cell-free plasma DNA following acute aseptic inflammation induced by exercise
- Fatouros, I. G.
- Jamurtas, A. Z.
- Nikolaidis, M. G.
- Destouni, A.
- Michailidis, Y.
- Vrettou, C.
- Douroudos, II
- Avloniti, A.
- Chatzinikolaou, A.
- Taxildaris, K.
- Kanavakis, E.
- Papassotiriou, I.
- Kouretas, D.
DOIAbstract
Objectives: To determine the time-course changes of cell-free plasma DNA (cfDNA) following heavy exercise. Methods: cfDNA concentration, C-reactive protein levels (hs-CRP), uric acid concentration (UA), creatine kinase activity (CK) were measured before and post-exercise (immediately post, 0.5 h, 1 h, 2 h, 3 h, 4 h, 5 h, 6 h, 8 h, 10 h, 24 h). Results: cfDNA increased (15-fold) 30-min post-exercise and normalized thereafter. hs-CRP increased (56%, p<0.001) 1 h post-exercise, remained elevated throughout recovery (52-142%, p<0.0001), and peaked (200% rise, p<0.0001) at 24 h post-exercise. UA and CK increased (p<0.05), immediately post-exercise, remained elevated throughout recovery (p<0.0001), and peaked (p<0.0001) at 24 h of post-exercise r...
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