Mnn2 gene affects drug resistance in Candida glabratas biofilms

Eurobiofilms 2017 - 5th European Congress on Microbial BiofilmsInfections caused by Candida species have increased worldwide substantially over the latest decades, and are a significant cause of morbidity and mortality, mostly among critically ill patients. Candida glabrata is the second most common Candida responsible for these infections in the USA and the third in Europe, and is characterized by a high antifungal resistance. The goal of this study was to understand the role of mannans in C. glabrata biofilms and in biofilm cells resistance to antifungal drugs (fluconazole - Flu, amphotericin B - AmB, caspofungin - Csf and micafungin - Mcf)This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte