Desorption of artemisinin extracts of CIM-Arogya by supercritical carbon dioxide

6siArtemisinin is a drug for chloroquine resistant malaria and cerebral malaria treatments. In the recent past, there was an acute shortage of this drug and hence World Health Organization made a strategy to fulfil the Artemisinin demand. In this study, artemisinin was extracted by supercritical Carbon Dioxide (SFCO2) from CIM-Arogya, a variety of Artemisia annua, in temperature and pressure ranges of 313.1-333.1 K and 15–25 MPa. Artemisinin global yield isotherms were determined obtaining a maximum yield of 3.65 wt%. Artemisinin extracts were also obtained by hexane Soxhlet extraction: then, the crude extracts were purified using SFCO2, after adsorption on silica gel. Different desorption runs were performed with a 6 ml/min CO2 flow rate, in temperature and pressure ranges of 313.1–333.1 K and 15–25 MPa. At different time intervals, extracts were collected and analysed: their yields varied from 2.75% to 4.34% function of the experimental conditions. Desorption trials were also correlated with different models.openembargoed_20190923Negi, Arvind Singh; Cortesi, Angelo; Kikic, Ireneo; Bertucco, Alberto; Calabrese, Massimo; Solinas, DarioNegi, Arvind Singh; Cortesi, Angelo; Kikic, Ireneo; Bertucco, Alberto; Calabrese, Massimo; Solinas, Dari