Background: Phenylketonuria (PKU) is a rare inborn error of metabolism often complicated by a progressive bone impairment of uncertain etiology, as documented by both ionizing and non-ionizing techniques. Methodology: Peripheral blood mononuclear cell (PBMC) cultures were performed to study osteoclastogenesis, in the presence or absence of recombinant human monocyte-colony stimulating factor (M-CSF) and receptor activator of NFkB ligand (RANKL). Flow cytometry was utilized to analyze osteoclast precursors (OCPs) and T cell phenotype. Tumour necrosis factor alpha (TNF-alpha), RANKL and osteoprotegerin (OPG) were quantified in cell culture supernatants by ELISA. The effects of RANKFc and anti-TNF-alpha antibodies were also investigated to det...
Osteoclasts are unique multinuclear cells that are highly specialized for resorbing bone tissue and ...
Alkaptonuria (AKU) is a rare disorder characterized by the deficiency of the enzyme homogentisate 1,...
AIMS/HYPOTHESIS: Our aims were to compare osteoclastic activity between patients with acute Charcot'...
BACKGROUND: Phenylketonuria (PKU) is a rare inborn error of metabolism often complicated by a progre...
Phenylketonuria (PKU) is a rare inborn error of metabolism often complicated by a progressive bone i...
Phenylketonuria (PKU) is commonly complicated by a progressive bone impairment of uncertain aetiolog...
International audiencePurpose of review: To describe the methods that can be used to obtain function...
Local priming of osteoclast precursors (OCp) has long been considered the main and obvious pathway t...
Objective: Most of phenylketonuria (PKU) develops bone turnover impairment and low bone mineral dens...
Osteoporosis is a common complication of chronic liver disease, and the underlying mechanisms are no...
Background. Inflammation and immune system alterations contribute to bone damage in many pathologies...
Recent literature indicates that osteoclast formation in vitro from peripheral blood of patients wit...
A characteristic feature of Paget's disease is an increase in the number of osteoclasts in bone. Ost...
Aims: To investigate whether idiopathic osteonecrosis of the femoral head (ONFH) is related to impai...
Aims/hypothesis: Our aims were to compare osteoclastic activity between patients with acute Charcot'...
Osteoclasts are unique multinuclear cells that are highly specialized for resorbing bone tissue and ...
Alkaptonuria (AKU) is a rare disorder characterized by the deficiency of the enzyme homogentisate 1,...
AIMS/HYPOTHESIS: Our aims were to compare osteoclastic activity between patients with acute Charcot'...
BACKGROUND: Phenylketonuria (PKU) is a rare inborn error of metabolism often complicated by a progre...
Phenylketonuria (PKU) is a rare inborn error of metabolism often complicated by a progressive bone i...
Phenylketonuria (PKU) is commonly complicated by a progressive bone impairment of uncertain aetiolog...
International audiencePurpose of review: To describe the methods that can be used to obtain function...
Local priming of osteoclast precursors (OCp) has long been considered the main and obvious pathway t...
Objective: Most of phenylketonuria (PKU) develops bone turnover impairment and low bone mineral dens...
Osteoporosis is a common complication of chronic liver disease, and the underlying mechanisms are no...
Background. Inflammation and immune system alterations contribute to bone damage in many pathologies...
Recent literature indicates that osteoclast formation in vitro from peripheral blood of patients wit...
A characteristic feature of Paget's disease is an increase in the number of osteoclasts in bone. Ost...
Aims: To investigate whether idiopathic osteonecrosis of the femoral head (ONFH) is related to impai...
Aims/hypothesis: Our aims were to compare osteoclastic activity between patients with acute Charcot'...
Osteoclasts are unique multinuclear cells that are highly specialized for resorbing bone tissue and ...
Alkaptonuria (AKU) is a rare disorder characterized by the deficiency of the enzyme homogentisate 1,...
AIMS/HYPOTHESIS: Our aims were to compare osteoclastic activity between patients with acute Charcot'...