Computational cognitive models developed so far do not incorporate individual differences in domain knowledge in predicting user clicks on search result pages. We address this problem using a cognitive model of information search which enables us to use two semantic spaces having a low (non-expert semantic space) and a high (expert semantic space) amount of medical and health related information to represent respectively low and high knowledge of users in this domain. We also investigated two different processes along which one can gain a larger amount of knowledge in a domain: an evolutionary and a common core process. Simulations of model click behavior on difficult information search tasks and subsequent matching with actual behavioral d...