Add to ORKGThe G2019S mutation within the LRRK2 gene, is the most common genetic cause of Parkinson’s, being responsible for 20-40% of all familial PD cases, depending on the population under study. The actual function of the LRRK2 protein is not yet clear, although it has been implicated in several pathways including synaptic vesicle regulation, endocytosis and membrane trafficking. The gain of function G2019S mutation increases the kinase activity of the LRRK2 protein, contributing to the pathogenesis of PD. Several hypotheses exist on how G2019S contributes to PD, including regulation of dopamine metabolism and/or several Rab proteins, which have been identified as binding LRRK2, but the exact Rab is not consistent. Using the Drosophila visual syst...
International audienceMutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal ...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Park...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Park...
The G2019S mutation within the LRRK2 gene, is the most common genetic cause of Parkinson’s, being re...
Although the pathogenesis of Parkinsonâ s disease (PD) remains unclear, mutations in leucine-rich r...
Although the pathogenesis of Parkinsonâ s disease (PD) remains unclear, mutations in leucine-rich r...
The kinase domain LRRK2-G2019S mutation is the most common cause of familial Parkinson’s disease (PD...
Within neurodegenerative syndromes, Parkinson’s disease (PD) is typically associatedwith its locomot...
Our understanding of Parkinson’s disease (PD) has been revolutionized by the discovery of disease-ca...
Within neurodegenerative syndromes, Parkinson’s disease (PD) is typically associatedwith its locomot...
Our understanding of Parkinson’s disease (PD) has been revolutionized by the discovery of disease-ca...
Our understanding of Parkinson’s disease (PD) has been revolutionized by the discovery of disease-ca...
Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder characterized by the l...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Park...
International audienceMutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal ...
International audienceMutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal ...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Park...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Park...
The G2019S mutation within the LRRK2 gene, is the most common genetic cause of Parkinson’s, being re...
Although the pathogenesis of Parkinsonâ s disease (PD) remains unclear, mutations in leucine-rich r...
Although the pathogenesis of Parkinsonâ s disease (PD) remains unclear, mutations in leucine-rich r...
The kinase domain LRRK2-G2019S mutation is the most common cause of familial Parkinson’s disease (PD...
Within neurodegenerative syndromes, Parkinson’s disease (PD) is typically associatedwith its locomot...
Our understanding of Parkinson’s disease (PD) has been revolutionized by the discovery of disease-ca...
Within neurodegenerative syndromes, Parkinson’s disease (PD) is typically associatedwith its locomot...
Our understanding of Parkinson’s disease (PD) has been revolutionized by the discovery of disease-ca...
Our understanding of Parkinson’s disease (PD) has been revolutionized by the discovery of disease-ca...
Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder characterized by the l...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Park...
International audienceMutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal ...
International audienceMutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal ...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Park...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Park...