The carotid body does not mediate the acute ventilatory effects of leptin

Leptin is a hormone produced mostly in adipose tissue and playing a key role in the control of feeding and energy expenditure aiming to maintain a balance between food intake and metabolic activity. In recent years, it has been described that leptin might also contributes to control ventilation as the administration of the hormone reverses the hypoxia and hypercapnia commonly encountered in ob/ob mice which show absence of the functional hormone. In addition, it has been shown that the carotid body (CB) of the rat expresses leptin as well as the functional leptin-B receptor. Therefore, the possibility exists that the ventilatory effects of leptin are mediated by the CB chemoreceptors. In the experiments described below we confi rm the stimulatory effect of leptin on ventilation, fi nding additionally that the CB does not mediate the instant to instant control of ventilation.Supported by grants BFU2012- 37459 and CIBER CB06/06/0050 to CG (Spain) and EXPL/NEUSCC/2183/2013 to SVC from Portugal.Peer Reviewe