The invention provides highly functionalised spiro-fused azetidinones of formula I: having a cyclohexane moiety with the desired number of protected or unprotected hydroxyl groups or carbonated structures, which are introduced with high stereo and regioselectivity, as well as processes for their obtention.Peer reviewedLaboratorios del Dr. Esteve S.A.A1 Solicitud de patente con informe sobre el estado de la técnic
The synthesis of constrained spirocycles is achieved effectively by means of 1,3-dipolar cyclodditio...
Alkaloids from the family of the tetrahydroisoquinolins exhibit powerful antitumor and antibiotic ac...
Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Sp...
The invention provides highly functionalised spiro-fused azetidinones of formula (I) having a cycloh...
The inventlon provides highly functionahsed spiro-fused azetidinones having a cyclohexane moiety wit...
The invention provides highly functionalised spiro-fused lac tams of en formula (I) having a cycloh...
New spirolactams of formula (I) having a benzodienone moiety and a azetidinone moiety which are high...
The present invention refers to a process for rearranging a spirolactam (I) under acidic conditions ...
The invention provides highly functionalised spiro-fused lactams of formula (1) having a cyclohexane...
International audienceThis work describes a modular efficient route to 10-aza-4-thia-, 10-aza-4-oxa-...
Les travaux décrits dans ce manuscrit de thèse ont porté d'une part sur le développement de nouvelle...
Après avoir exposé les enjeux de ce travail en présentant dans le chapitre 1 les produits naturels p...
International audiencePolycyclic structures fused at a central carbon are of great interest due to t...
Depuis quelques années, l’élaboration de molécules spiraniques connait un essor considérable avec, e...
The enantioselective total synthesis of spirofungins A (1) and B (2) is reported in 14 steps over th...
The synthesis of constrained spirocycles is achieved effectively by means of 1,3-dipolar cyclodditio...
Alkaloids from the family of the tetrahydroisoquinolins exhibit powerful antitumor and antibiotic ac...
Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Sp...
The invention provides highly functionalised spiro-fused azetidinones of formula (I) having a cycloh...
The inventlon provides highly functionahsed spiro-fused azetidinones having a cyclohexane moiety wit...
The invention provides highly functionalised spiro-fused lac tams of en formula (I) having a cycloh...
New spirolactams of formula (I) having a benzodienone moiety and a azetidinone moiety which are high...
The present invention refers to a process for rearranging a spirolactam (I) under acidic conditions ...
The invention provides highly functionalised spiro-fused lactams of formula (1) having a cyclohexane...
International audienceThis work describes a modular efficient route to 10-aza-4-thia-, 10-aza-4-oxa-...
Les travaux décrits dans ce manuscrit de thèse ont porté d'une part sur le développement de nouvelle...
Après avoir exposé les enjeux de ce travail en présentant dans le chapitre 1 les produits naturels p...
International audiencePolycyclic structures fused at a central carbon are of great interest due to t...
Depuis quelques années, l’élaboration de molécules spiraniques connait un essor considérable avec, e...
The enantioselective total synthesis of spirofungins A (1) and B (2) is reported in 14 steps over th...
The synthesis of constrained spirocycles is achieved effectively by means of 1,3-dipolar cyclodditio...
Alkaloids from the family of the tetrahydroisoquinolins exhibit powerful antitumor and antibiotic ac...
Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Sp...