Impact of multiple ionic changes in arrhythmic risk biomarkers in human ventricular electrophysiology

Electrophysiological variability represents an important challenge in evaluating cardiac response to disease and drug action. Our goal is to quantitatively evaluate the sensitivity of biomarkers to the simultaneous alteration of several ionic current in human cardiomyocytes. Computer simulations of human ventricular electrophysiology are conducted using an action potential (AP) model proposed by Carro et al..