Bone marrow 1D and 2D correlation MR spectroscopy at 7T

The altered chemistry of bone marrow has been shown to be indicative of disease. One-dimensional (1D) proton magnetic resonance spectroscopy (MRS) at 1.5T has previously been used to non-invasively investigate a range of diseases including musculoskeletal tumors , anorexia nervosa , multiple myeloma and osteoporosis . The ratio of saturated to unsaturated lipids was indicative of diagnostic markers for osteoporosis. Two-dimensional (2D) MRS has been shown to be particularly amenable to monitoring lipid alterations with disease. In an attempt to unambiguously assign and monitor resonances, localized 2D correlation spectroscopy (L-COSY) of bone marrow at 1.5T was used to study acute leukemia patients. The results were ambiguous due to crosspeak overlap. The goal of the present study is to develop the L-COSY method to study bone marrow at the higher field strength of 7T and separate those lipid resonances that were composites at 1.5T