Bone tissue engineering in two preclinical ovine animal models

This PhD-research was focused on the development and evaluation of innovative scaffold-based bone tissue engineering concepts for the treatment of large volume bone defects, which still represent a major challenge in orthopaedic and reconstructive surgery. Two different types of bone tissue engineering constructs were investigated and successfully applied to regenerate critically-sized segmental bone defects in ovine animal models. The results outlined in the PhD thesis represent a significant contribution to potential future clinical translations of bone tissue engineering concepts from bench to bedside