Use of Assisted Reproduction Techniques in Male Pathologies: Molecule Based Sperm Selection Methods
- Marini, Patricia Estela
- Munuce, María José
- Caille, Adriana María
- Zumoffen, Carlos
- Teijeiro, Juan Manuel
DOIAbstract
Infertility is a widespread problem that is found in over 15% of couples. In 50 % of the cases, the male factor is the key. In order to improve pregnancy rates in assisted reproductive techniques (ART), new methods to select sperm subpopulations are required. These methods are under constant evaluation, and their possible genetic and epigenetic effects on the offspring must be considered. New concepts such as DNA fragmentation and sperm apoptosis are being introduced in andrology and are considered to develop new techniques. Recently, molecule-based methods have been developed for the purpose of overcoming deficiencies in classical selection methods that involve sperm morphology and movement. One of these methods is physiologic intracytopla...
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