Validation of single nucleotide polymorphisms associated with acute kidney injury in bone marrow transplant recipients

Thesis (Master's)--University of Washington, 2013Validation of single nucleotide polymorphisms associated with acute kidney injury in bone marrow transplant recipients Laurel K. Willig Timothy Thornton Background: Rates of acute kidney injury (AKI) as high as 75% have been reported in hematopoietic stem cell transplant (HSCT) patients. Previous studies have identified single nucleotide polymorphisms (SNP) associated with AKI. However, few studies, have examined genetic associations with AKI in HSCT recipients. Methods: We perform a case-control analysis in a sample of 795 HSCT recipients who developed AKI and 1052 HSCT recipients without AKI. 18 SNPs that were previously identified as candidates for AKI were tested for association using multivariate logistic regression models. Results: We identified three genetic polymorphisms associated with developing AKI. The T allele in rs3024495 and the C allele in rs1800896 of interleukin 10 (IL-10) both decreased the odds of developing AKI (OR=0.75, p=0.0029 and OR=0.84, p=0.011 respectively). The C allele for rs4540055 in toll-like receptor 1 (TLR1) increased the odds of developing AKI (OR=1.84, p=0.0016). Both rs3034495 and rs4540055 remained significant after adjustment for covariates. Conclusions: Genetic polymorphisms in IL-10 and TLR1 were associated with AKI development in HSCT recipients