Extraocular motoneurons resist degeneration in diseases such as amyotrophic lateral sclerosis. The main objective of the present work was to characterize the presence of neurotrophins in extraocular motoneurons and muscles of the adult rat. We also compared these results with those obtained from other cranial motor systems, such as facial and hypoglossal, which indeed suffer neurodegeneration. Immunocytochemical analysis was used to describe the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in oculomotor, trochlear, abducens, facial, and hypoglossal nuclei of adult rats, and Western blots were used to describe the presence of neurotrophins in extraocular, facial (buccinator), and tongue muscles, whi...
Because of discrepancies in previous reports regarding the role of glial cell line-derived neurotrop...
Amyotrophic lateral sclerosis (ALS) is currently an incurable fatal motor neuron syndrome characteri...
We have demonstrated that the extensive degener-ation of motoneurons in the rat facial nucleus after...
Neurotrophins play a principal role in neuronal survival and differentiation during development, but...
Recent studies show a relationship between the deficit of vascular endothelial growth factor (VEGF) ...
Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involv...
Motoneuron diseases represent a m&jor challenge to modern neurology, yet their clinical manifestatio...
Spinal motoneurons innervating skeletal muscle were amongst the first neurons shown to require the p...
Previous studies suggest that neurotrophins support regeneration and survival of injured motoneurons...
Neurotrophins play a crucial role in the regulation of survival and maintenance of specific function...
We have studied the mRNA expression of the neurotrophins brain-derived neurotrophic factor (BDNF), N...
We have studied the mRNA expression of the neurotrophins brain-derived neurotrophic factor (BDNF), N...
The survival of the mammalian peripheral nervous system neurons has long been known to depend on neu...
In this report, we have tested the hypothesis that brain-derived neurotrophic factor (BDNF) is an an...
Recent studies have shown that the survival of mammalian motoneurons in vitro is promoted by neurotr...
Because of discrepancies in previous reports regarding the role of glial cell line-derived neurotrop...
Amyotrophic lateral sclerosis (ALS) is currently an incurable fatal motor neuron syndrome characteri...
We have demonstrated that the extensive degener-ation of motoneurons in the rat facial nucleus after...
Neurotrophins play a principal role in neuronal survival and differentiation during development, but...
Recent studies show a relationship between the deficit of vascular endothelial growth factor (VEGF) ...
Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involv...
Motoneuron diseases represent a m&jor challenge to modern neurology, yet their clinical manifestatio...
Spinal motoneurons innervating skeletal muscle were amongst the first neurons shown to require the p...
Previous studies suggest that neurotrophins support regeneration and survival of injured motoneurons...
Neurotrophins play a crucial role in the regulation of survival and maintenance of specific function...
We have studied the mRNA expression of the neurotrophins brain-derived neurotrophic factor (BDNF), N...
We have studied the mRNA expression of the neurotrophins brain-derived neurotrophic factor (BDNF), N...
The survival of the mammalian peripheral nervous system neurons has long been known to depend on neu...
In this report, we have tested the hypothesis that brain-derived neurotrophic factor (BDNF) is an an...
Recent studies have shown that the survival of mammalian motoneurons in vitro is promoted by neurotr...
Because of discrepancies in previous reports regarding the role of glial cell line-derived neurotrop...
Amyotrophic lateral sclerosis (ALS) is currently an incurable fatal motor neuron syndrome characteri...
We have demonstrated that the extensive degener-ation of motoneurons in the rat facial nucleus after...