27th European Symposium on Computer Aided Process Engineering (ESCAPE 27), Barcelona, 1st-5th October, 2017.Environmental impacts related to increasing greenhouse gas emissions and depletion of fossil-fuel reserves and water resources are major global concerns. In this work, we introduce a new multi-objective optimization model for simultaneous synthesis of zero-emission desalination plants driven by renewable energy. The system is particularly developed for zero-liquid discharge (ZLD) desalination of high-salinity shale gas wastewater, aiming to enhance economic and environmental system performance. The mathematical model is based on a multistage superstructure, which integrates a solar assisted Rankine cycle to a multiple-effect evaporati...