International audienceIn order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adjuvant properties of a non-toxic derivative of Escherichia coli heat labile enterotoxin (LT), LTAK63. We have constructed rBCG strains expressing LTAK63 at different expression levels. Mice immunized with BCG expressing low levels of LTAK63 (rBCG-LTAK63lo) showed higher Th1 cytokines and IL-17 in the lungs, and when challenged intratracheally with Mycobacterium tuberculosis displayed a 2.0-3.0 log reduction in CFU as compared to wild type BCG. Histopathological analysis of lung tissues from protected mice revealed a reduced inflammatory response. Immunization with rBCG-LTAK63lo also protected against a 100-fold higher chal...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
International audienceIn order to develop an improved BCG vaccine against tuberculosis we have taken...
In order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adju...
Tuberculosis (TB) is one of the top 10 leading causes of death worldwide. The recombinant BCG strain...
Tuberculosis (TB) is one of the top 10 leading causes of death worldwide. The recombinant BCG strain...
The bacillus Calmette–Guérin (BCG) is an attenuated Mycobacterium bovis derivative that has been wid...
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) that is a majo...
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) that is a majo...
Bacille Calmette-Guérin (BCG) is the vaccine against tuberculosis (TB), but has varied efficacy in d...
Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb), remains a...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
International audienceIn order to develop an improved BCG vaccine against tuberculosis we have taken...
In order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adju...
Tuberculosis (TB) is one of the top 10 leading causes of death worldwide. The recombinant BCG strain...
Tuberculosis (TB) is one of the top 10 leading causes of death worldwide. The recombinant BCG strain...
The bacillus Calmette–Guérin (BCG) is an attenuated Mycobacterium bovis derivative that has been wid...
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) that is a majo...
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) that is a majo...
Bacille Calmette-Guérin (BCG) is the vaccine against tuberculosis (TB), but has varied efficacy in d...
Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb), remains a...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...
One possibility to improve the efficacy of BCG vaccine against TB is to create a recombinant BCG (r-...