Therapeutic applications of rose hips from different rosa species

Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer. In this review, the role of different species of Rosa in the prevention of treatment of various disorders related to oxidative stress, is examined, focusing on new therapeutic approaches from a molecular point of view.The work of this group was supported by projects from the Ministerio de Ciencia e Innovación (SAF2016-75441-R), funding from the Gobierno de Aragón/European Regional Development Fund (ERDF) (A-32), and Proyect Interreg Sudoe REDVALUE (SOE1/PI/E0123) Co-financed at 65% by the European Regional (A-32), and Proyect Interreg Sudoe REDVALUE (SOE1/PI/E0123) Co-financed at 65% by the European Regional Development Fund. We are also grateful for the financing of CIBERobn (CB06/03/1012) from the Instituto Carlos III (Spain)