Medicine and engineering related researches on the utility of two dimensional nuchal translucency

A thorough literature review on current research for trisomy 21 detection using ultrasound will be carried out for existing modality’s drawback investigation. Due to its critical restriction, computing on ultrasound markers in term of its recognition, segmentation and measurement are essentially required. 3D reconstruction of nuchal translucency becomes a breakthrough to select the appropriate scanning plane of ultrasound markers. It shall resolve the problematic issue on scanning plane selections which depends on operator assumption and experience. Data sources from hospital patient scanning should obtain the approval from Medicine ethical committee. Consent and simple agreement document shall be prepared. The main ultrasound images sources will be taken from Health Center Universiti Teknologi Malaysia, Hospital Universiti Sains Malaysia, and Hospital Universiti Kebangsaan Malaysia. External collaboration parties are Hospital Sultanah Aminah and Technische Universitat Ilmenau, Germany. Other than fetal data, maternal health data will also be recorded. This data is important to obtain the knowledge of correlation between fetal and mother data. It is recommended that pregnant women should be older than 30 years old. This chapter will describe the book in terms of its background, history and the related works in greater detail. The focus will be on the Trisomy 21 background, history, existing detection techniques, and ultrasound application using 2D and 3D image formation on fetal abnormalities detection. Previous related research works are discussed and each of their limitation is remarked