Okaramines produced by Penicillium simplicissimum AK-40 activate l-glutamate-gated chloride channels (GluCls) and thus paralyze insects. However, the okaramine binding site on insect GluCls is poorly understood. Sequence alignment shows that the equivalent of residue Leucine319 of the okaramine B sensitive Bombyx mori (B. mori) GluCl is a phenylalanine in the okaramine B insensitive B. mori γ-aminobutyric acid-gated chloride channel of the same species. This residue is located in the third transmembrane (TM3) region, a location which in a nematode GluCl is close to the ivermectin binding site. The B. mori GluCl containing the L319F mutation retained its sensitivity to l-glutamate, but responses to ivermectin were reduced and those to okaram...
Glutamate-gated chloride channels (GluCls) are found only in invertebrates and mediate fast inhibito...
Glutamate‐gated chloride (GluCl) channels from invertebrates can be activated by ivermectin (IVM) to...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
The okaramine indole alkaloids were recently shown to be more selective than ivermectin in activatin...
The okaramine indole alkaloids were recently shown to be more selective than ivermectin in activatin...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
Abamectin is one of the most widely used avermectins for agricultural pests control, but the emergen...
Ivermectin (IVM) is a widely-used anthelmintic that works by binding to and activating glutamate-gat...
Abamectin is one of the most widely used avermectins for agricultural pests control, but the emergen...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
BACKGROUND: The cys-loop ligand-gated ion channels, including the glutamate-gated chloride channel (...
Glutamate-gated chloride channel receptors (GluClRs) mediate inhibitory neurotransmission at inverte...
Glutamate‐gated chloride (GluCl) channels from invertebrates can be activated by ivermectin (IVM) to...
Glutamate-gated chloride channels (GluCls) are found only in invertebrates and mediate fast inhibito...
Glutamate‐gated chloride (GluCl) channels from invertebrates can be activated by ivermectin (IVM) to...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
The okaramine indole alkaloids were recently shown to be more selective than ivermectin in activatin...
The okaramine indole alkaloids were recently shown to be more selective than ivermectin in activatin...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
Abamectin is one of the most widely used avermectins for agricultural pests control, but the emergen...
Ivermectin (IVM) is a widely-used anthelmintic that works by binding to and activating glutamate-gat...
Abamectin is one of the most widely used avermectins for agricultural pests control, but the emergen...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...
BACKGROUND: The cys-loop ligand-gated ion channels, including the glutamate-gated chloride channel (...
Glutamate-gated chloride channel receptors (GluClRs) mediate inhibitory neurotransmission at inverte...
Glutamate‐gated chloride (GluCl) channels from invertebrates can be activated by ivermectin (IVM) to...
Glutamate-gated chloride channels (GluCls) are found only in invertebrates and mediate fast inhibito...
Glutamate‐gated chloride (GluCl) channels from invertebrates can be activated by ivermectin (IVM) to...
A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixo...