Add to ORKGOverall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B*1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no ...
Genetic resistance to infectious diseases is likely to involve a complex array of immune-response an...
The genetics of resistance to infection by HIV-1 cohort consists of 200 slow and 75 rapid progressor...
Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, the...
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
In West Africa, the Acquired Immunodeficiency Syndrome (AIDS) is caused by both types of Human Immun...
BACKGROUND: The HLA class II molecules play a central role in the generation of human immunodeficien...
Natural killer (NK) cells are regulated by interactions between polymorphic killer immunoglobulin-li...
Background. The HLA class II molecules play a central role in the generation of human immunodeficien...
Natural killer (NK) cells are regulated by interactions between polymorphic killer immunoglobulin-li...
Previous studies have identified a central role for HLA-B alleles in influencing control of HIV infe...
Variation in the host response to infection by pathogens including HIV-1 may be conferred by polymor...
NK cell receptors and HLA molecules are intimately involved in the immune response against viral inf...
Polymorphic products of genes in the HLA region contributing to variability in the course of human i...
Objective: The objective of this study is to identify human leukocyte antigen (HLA) class I and kil...
BACKGROUND: During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable...
Genetic resistance to infectious diseases is likely to involve a complex array of immune-response an...
The genetics of resistance to infection by HIV-1 cohort consists of 200 slow and 75 rapid progressor...
Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, the...
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
In West Africa, the Acquired Immunodeficiency Syndrome (AIDS) is caused by both types of Human Immun...
BACKGROUND: The HLA class II molecules play a central role in the generation of human immunodeficien...
Natural killer (NK) cells are regulated by interactions between polymorphic killer immunoglobulin-li...
Background. The HLA class II molecules play a central role in the generation of human immunodeficien...
Natural killer (NK) cells are regulated by interactions between polymorphic killer immunoglobulin-li...
Previous studies have identified a central role for HLA-B alleles in influencing control of HIV infe...
Variation in the host response to infection by pathogens including HIV-1 may be conferred by polymor...
NK cell receptors and HLA molecules are intimately involved in the immune response against viral inf...
Polymorphic products of genes in the HLA region contributing to variability in the course of human i...
Objective: The objective of this study is to identify human leukocyte antigen (HLA) class I and kil...
BACKGROUND: During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable...
Genetic resistance to infectious diseases is likely to involve a complex array of immune-response an...
The genetics of resistance to infection by HIV-1 cohort consists of 200 slow and 75 rapid progressor...
Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, the...