Pyrrolizidine alkaloids (PAs) are a group of natural products with important biological activities. The discovery and characterization of the multifunctional FAD-dependent enzyme LgnC is now described. The enzyme is shown to convert indolizidine intermediates into pyrrolizidines through an unusual ring expansion/contraction mechanism, and catalyze the biosynthesis of new bacterial PAs, the so-called legonmycins. By genome-driven analysis, heterologous expression, and gene inactivation, the legonmycins were also shown to originate from non-ribosomal peptide synthetases (NRPSs). The biosynthetic origin of bacterial PAs has thus been disclosed for the first time
Actinomycetes make a wealth of complex, structurally diverse natural products, and a key challenge i...
International audienceThe naturally occurring diazobenzofluorenes, kinamycins, fluostatins and lomai...
Lytic polysaccharide monooxygenases (LPMOs) are a recently discovered class of enzymes capable of ox...
Pyrrolizidine alkaloids (PAs) are a group of natural products with important biological activities. ...
We report the formicapyridines which are structurally and biosynthetically related to the pentacycli...
Natural products are essential to the discovery of new drugs, including antibiotics. Industrial inte...
Actinobacteria possess a great wealth of pathways for production of bioactive compounds. Following a...
SummaryPyrrolopyrimidine nucleosides analogs, collectively referred to as deazapurines, are an impor...
Salinosporamide A, a highly bioactive [beta]-lactone from the marine bacterium Salinispora tropica, ...
Lysobacter is a genus of Gram-negative bacteria and a new source for bioactive natural products. Thi...
Within the framework of our genome-based program to discover new antibiotic lipopeptides from Pseudo...
Anthracyclines are an important group of aromatic antibiotics that exhibit antitumour activity, whic...
The naturally occurring diazobenzofluorenes, kinamycins, fluostatins and lomaiviticins, possess high...
AbstractBackground: The non-proteinogenic amino acid p-hydroxyphenylglycine is a crucial component o...
SummaryJadomycin B is a member of atypical angucycline antibiotics whose biosynthesis involves a uni...
Actinomycetes make a wealth of complex, structurally diverse natural products, and a key challenge i...
International audienceThe naturally occurring diazobenzofluorenes, kinamycins, fluostatins and lomai...
Lytic polysaccharide monooxygenases (LPMOs) are a recently discovered class of enzymes capable of ox...
Pyrrolizidine alkaloids (PAs) are a group of natural products with important biological activities. ...
We report the formicapyridines which are structurally and biosynthetically related to the pentacycli...
Natural products are essential to the discovery of new drugs, including antibiotics. Industrial inte...
Actinobacteria possess a great wealth of pathways for production of bioactive compounds. Following a...
SummaryPyrrolopyrimidine nucleosides analogs, collectively referred to as deazapurines, are an impor...
Salinosporamide A, a highly bioactive [beta]-lactone from the marine bacterium Salinispora tropica, ...
Lysobacter is a genus of Gram-negative bacteria and a new source for bioactive natural products. Thi...
Within the framework of our genome-based program to discover new antibiotic lipopeptides from Pseudo...
Anthracyclines are an important group of aromatic antibiotics that exhibit antitumour activity, whic...
The naturally occurring diazobenzofluorenes, kinamycins, fluostatins and lomaiviticins, possess high...
AbstractBackground: The non-proteinogenic amino acid p-hydroxyphenylglycine is a crucial component o...
SummaryJadomycin B is a member of atypical angucycline antibiotics whose biosynthesis involves a uni...
Actinomycetes make a wealth of complex, structurally diverse natural products, and a key challenge i...
International audienceThe naturally occurring diazobenzofluorenes, kinamycins, fluostatins and lomai...
Lytic polysaccharide monooxygenases (LPMOs) are a recently discovered class of enzymes capable of ox...