Host Transcription Profile in Nasal Epithelium and Whole Blood of Hospitalized Children Under 2 Years of Age With Respiratory Syncytial Virus Infection.
- Do, Lien Anh Ha
- Pellet, Johann
- van Doorn, H Rogier
- Tran, Anh Tuan
- Nguyen, Bach Hue
- Tran, Thi Thu Loan
- Tran, Quynh Huong
- Vo, Quoc Bao
- Tran Dac, Nguyen Anh
- Trinh, Hong Nhien
- Nguyen, Thi Thanh Hai
- Le Binh, Bao Tinh
- Nguyen, Huu Mai Khanh
- Nguyen, Minh Tien
- Thai, Quang Tung
- Vo, Thanh Vu
- Ngo, Ngoc Quang Minh
- Dang, Thi Kim Huyen
- Cao, Ngoc Huong
- Tran, Thu Van
- Ho, Lu Viet
- De Meulder, Bertrand
- Auffray, Charles
- Hofstra, Jorrit-Jan
- Farrar, Jeremy
- Bryant, Juliet E
- de Jong, Menno
- Hibberd, Martin L
DOIAbstract
BACKGROUND: Most insights into the cascade of immune events after acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. METHODS: In this study, we investigated host gene expression profiles in nasopharyngeal (NP) swabs and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalized patients <2 years old with lower respiratory tract infections. RESULTS: Respiratory syncytial virus infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments. Interferon-α/β, NOTCH1 signaling pathways and potential biomarkers HIST1H...
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