Purpose. To explore the effect and possible mechanism of icariin, a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum that was applied to IL-1β pretreated human nucleus pulposus (NP) cells. Methods. Human NP cells were isolated from intervertebral discs of patients with scoliosis and lumbar spondylolisthesis. The cells were divided into five groups: A (blank control); B (20 ng/ml IL-1β); C (20 ng/ml IL-1β + 20 μM icariin); D (20 μM icariin + 20 ng/ml IL-1β + 25 μM LY294002); E (20 ng/ml IL-1β + 25 μM LY294002). For each of the five groups, the CCK8, apoptosis rates, ROS rates, and JC-1 rates were determined and an electron micrograph was performed. Different expression levels of apoptosis proteins and proteins...
Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, ex...
Icaritin, a traditional Chinese medicine, possesses antitumor activity. The current study aimed to i...
Epimedium (family Berberidaceae), commonly known as Horny Goat Weed or Yin Yang Huo, is commonly use...
Icariin is a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum that e...
Microglia in the central nervous system (CNS) play an important role in the initiation of neuroinfla...
Synovial inflammation plays an important role in the pathogenesis and progress of osteoarthritis (OA...
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive loss o...
Osteoarthritis (OA) is a common chronic and degenerative joint condition that is mainly characterize...
Cartilage endplate (CEP) plays important roles in the onset and progression of intervertebral disc d...
Cartilage endplate (CEP) plays important roles in the onset and progression of intervertebral disc d...
Spinal cord injury (SCI) is a severe medical problem leading to crucial life change. Icariin (ICA) i...
Purpose. To investigate whether icariin (ICA), a well-known medicine extracted from the stem and lea...
Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, ex...
Cisplatin, as an effective chemotherapeutic agent, is widely used to treat verious types of cancers....
Oxidative stress caused by hydrogen peroxide (H(2)O(2)) plays an important role in the pathogenesis ...
Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, ex...
Icaritin, a traditional Chinese medicine, possesses antitumor activity. The current study aimed to i...
Epimedium (family Berberidaceae), commonly known as Horny Goat Weed or Yin Yang Huo, is commonly use...
Icariin is a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum that e...
Microglia in the central nervous system (CNS) play an important role in the initiation of neuroinfla...
Synovial inflammation plays an important role in the pathogenesis and progress of osteoarthritis (OA...
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive loss o...
Osteoarthritis (OA) is a common chronic and degenerative joint condition that is mainly characterize...
Cartilage endplate (CEP) plays important roles in the onset and progression of intervertebral disc d...
Cartilage endplate (CEP) plays important roles in the onset and progression of intervertebral disc d...
Spinal cord injury (SCI) is a severe medical problem leading to crucial life change. Icariin (ICA) i...
Purpose. To investigate whether icariin (ICA), a well-known medicine extracted from the stem and lea...
Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, ex...
Cisplatin, as an effective chemotherapeutic agent, is widely used to treat verious types of cancers....
Oxidative stress caused by hydrogen peroxide (H(2)O(2)) plays an important role in the pathogenesis ...
Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, ex...
Icaritin, a traditional Chinese medicine, possesses antitumor activity. The current study aimed to i...
Epimedium (family Berberidaceae), commonly known as Horny Goat Weed or Yin Yang Huo, is commonly use...