Pengaruh Ekstrak Etanol Buah Pinang Yaki (Areca Vestiaria ) Terhadap Gambaran Makroskopis Organ Lambung Pada Tikus Putih Jantan Galur Wistar (Rattus Norvegicus L.)

Pengaruh Ekstrak Etanol Buah Pinang Yaki (Areca vestiaria ) terhadap Gambaran Makroskopis Organ Lambung pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus L.) Rein A. Gosal1), Widdhi Bodhi1), Herny Simbala1)1)Program Studi Farmasi FMIPA UNSRAT Manado, 95115 ABSTRACTCrownshaft palm (Areca vestiaria) is one of the plants that grow in North Sulawesi region which is widely used to cure diseases such as diabetes, diarrhea, and as a contraceptive drug. This study aims to determine the effect from ethanolic extract of crownshaft palm fruit (Areca vestiaria) against the description of gastric organ macroscopically. The method used was experimental methods and male white rats wistar strain as research subjects, totaling 12 rats, which are divided into three groups of dose were given ethanol extract of crownshaft palm nuts orally (7.2 mg / mL 14.4 mg / mL, 21.6 mg / mL) and a group as a negative control for comparison. The tests were carried out for 40 days, with observations made against the body weight of rats, gastric organ macroscopically and the weights of organ.The results were of stomach macroscopic picture of rats with treatment shows no difference compared to negative control. In the analysis using one-way ANOVA test showed no significant difference in the results of the weighing of body weight and rat gastric organ weights (p> 0.05). The conclusion of this study was the crownshaft palm fruithas noinfluence, which can damage the stomach of wistar rats. Keywords: Crownshaft palm (Areca vestiaria), gastric macroscopic, white rat (Rattusnorvegicus). ABSTRAKPinang yaki (Areca vestiaria) adalah salah satu tumbuhan yang tumbuh di daerah Sulawesi Utara yang banyak digunakan untuk menyembuhkan penyakit seperti diabetes, diare, dan sebagai obat kontrasepsi. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol buah pinang yaki (Areca vestiaria) terhadap gambaran organ lambung secara makroskopis. Metode penelitian yang digunakan adalah metode eksperimental dan subjek penelitian menggunakan tikus putih jantan galur Wistar berjumlah 12 ekor, yang dibagi dalam tiga kelompok dosis yang diberi ekstrak etanol buah pinang yaki secara oral (7.2 mg/mL, 14.4 mg/mL, 21