Peran Kaspase Pada Apoptosis Sebagai Salah Satu Usaha Dalam Kemoterapi Kanker

Apoptotic is a programmed, manage form of  cell death through a signal transduction cascade which is genetically controlled. Besides taking role in a development system, immune system maintenance and tissue homeostatic, apoptotic is also the main response to chemotherapy. Apoptotic takes a significant role in cancer prevention and therapy. Apoptotic induced chemotherapy generally objects in the DNA destroying, cell membrane lipid component, and proliferation inhibition. So that the cancer therapy is expected to alter the signal transduction cascade to achieve homeostatic as balanced as the previous condition. Protease enzyme group, that is caspase, takes role in arranging and executing cell death apoptotically and is influenced by the p53 protein. Only some from 14 caspase group members do not involve in apoptotic mechanism. They which are called apoptotic initiators are caspase-2, 8, 9, and 10. While caspase-3, 6, and 7 are called the effectors or executors and are directly involved in cell destroying mechanism. Caspase-12 takes role in cytokine activation as well as mediating the apoptotic. It has been arranged in vivo researches and they that use cancer cell culture in order to comprehend the mechanisms involving caspase in chemotherapy inducing apoptotic process