Uji Aktivitas Antibakteri Fraksi Daun Sirih (Piper Betle L) Terhadap Pertumbuhan Bakteri Streptococcus Mutans Secara in Vitro

One of natural ingredient that is often used as a medicinal plant is betel leaf (Piper betle L). Streptococcus mutans is a gram-positive bacteria and normal flora of the oral cavity. Dental caries is a disease that is localized dental hard tissue damage that occurs due to the interaction between the host (teeth), bacteria, substrate (diet), and time. The purpose of this study was to determine the effectiveness of antibacterial fraction of betel leaf (Piper betle L) againt Streptococcus mutans bacterial growth in vitro. This research includes laboratory experimental study in vitro. The samples were bacterium Streptococcus mutans. Fraction of betel leaf samples were divided in 6 concentration, 10 mg/ml, 5 mg/ml, 2,5 mg/ml, 1,25 mg/ml, 0,625 mg/ml, 0,3125 mg/ml with a comparison of ciprofloxacin. Analyze data using homogeneity test using Levene test/Smirnov Kolmogorof,  T test , Anova and post thoc, all analyzes using SPSS . The results of this study showed that the active fraction is N-hexane. N-hexane fraction had a MIC value of 1,25 mg/ml against Streptococcus mutans bacteria. Class of active compounds are contained phenol. Based on the results of statistical tests ciprofloxacin was more effective when compared with N-hexane fraction of the bacteria Streptococcus mutans with p value < 0.05 Keywords : Streptococcus mutans , betel leaf (Piper betle L), experimental studies, in vitro. &nbsp