Uji Daya Hambat Jamur Endofit Akar Bakau Rhizophora Apiculata Terhadap Bakteri Staphylococcus Aureus Dan Escherichiae Coli

: Endophytic Fungus is a microbial resources whichexist in the plant tissues and produce bioactive compounds which potentially could be developed into raw materials for drugs/medicine, such as anticancer and antibiotics. Endophytic Fungi could be found on many plants, such as Rhizophora apiculata, one of the mangroves found in Indonesia. This research aims to procure the endophytic fungal isolates from the mangrove roots Rhizophora apiculataand to test the activity of anti-bacterial of endophytic fungi on bacterium Staphylococcus aureus andEscherichiae coli. This research was done in Pharmacology Laboratory Faculty of Medicine on Sam Ratulangi University, Manado from November 2013 to January 2014. This research was an experimental research in the laboratory using the Control Trial Design. The endophytic fungi was cultured on carbohydrate-rich media, and then the bioactivity on the experimental bacterium was tested. The result of the research showed that there were two endophytic fungals isolates procured, which were black fungi and white fungi. As antibacterial activity, both of the endophytic fungi showed that there was an inhibition at the two experimental fungis. The antibacterial's activity testing of mangrove roots Rhizophora apiculataon the growth of bacterial Staphylococcus aureusandEscherichiae coliwas showing an inhibitory effect to both of the fungi. Advance study are needed