Mitokondria Sebagai Target Terapi Kanker

Cancer cells have distinct characteristics from normal cells, which able to withstand to cell apoptosis induction. Mitochondria are organelles that play an important role in the endogenous pathway of cells apoptosis. Release of cytochrome C and other proapoptosis proteins from the mitochondria to the cytoplasm were inhibit by cancer cells through mitochondrial permeability stabilization mechanism and metabolic reprogramming. Today various cancer cell therapies were developed on a specific targets. Mitochondria is a potent target in the treatment of cancer cells. By knowing the natural characteristics of mitochondrial cancer cells, a development of cell based cancer therapies by specific organelles were expected to increase cancer cells apoptosis without causing normal cells apoptosis. Aims of this manuscripstare to further understand about cancer cells mechanism in modulating mitochondrial activity to avoid mitochondrial apoptotic cells response, as well as to study the mechanism of cell based cancer therapies by mitokondria